Middle-Latency Auditory-Evoked Potential in Acepromazine-Sedated Dogs

• Published in: Journal of veterinary internal medicine 2004-03, Vol.18 (2), p.196-200
• Main Authors: Murrell, Joanna C., de Groot, H.N.M., Haagen, A.J. Venker-van, van den Brom, W.E., Hellebrekers, L.J.
• Format: Article
• Language: English
• Subjects: Acepromazine - administration & dosage; Acepromazine - pharmacology; Acoustic Stimulation - instrumentation; Acoustic Stimulation - veterinary; Anesthesia - veterinary; Animals; Awake; Awareness - physiology; Dogs - physiology; Evoked Potentials, Auditory, Brain Stem - drug effects; Female; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacology; Injections, Intramuscular - veterinary; Male; Monitor; Neurophysiologic; Sedation
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/j.1939-1676.2004.tb00160.x

The middle‐latency auditory‐evoked potential (MLAEP) has been investigated as means of monitoring anesthesia in dogs. The goals of this study were to develop a technique to record MLAEPs in awake dogs and to determine the effects of sedation. The MLAEP was recorded in 12 dogs with and without sedation with acepromazine. Three needle electrodes were inserted SC. Click stimuli were delivered biaurally. Signal acquisition, averaging, and analysis were performed by software developed in‐house. Signals were recorded for 128 milliseconds, and the responses to 1,024 stimuli were averaged. The waveforms from 10 recordings were averaged, and the amplitudes and latencies of peaks that could be consistently identified were measured. Data measured were compared by means of a paired 2‐sided Student's t‐test. Interpretable MLAEPs were recorded in 10 of the 12 dogs. Three peaks were consistently identified (Pa, Nb, and Pb). The latencies of these peaks were significantly (P = .032, .035, and .028, respectively) shorter in awake (mean ± SD milliseconds) (Pa = 18.85 ± 1.36, Nb = 30.50 ± 3.55, and Pb = 47.70 ± 5.53) than in sedated (Pa = 22.40 ± 3.88, Nb = 35.75 ± 6.77, and Pb = 55.30 ± 10.55) dogs. The Pb amplitude was not significantly different (2.51 ± 1.30 sV awake and 2.19 ± 1.10 μV sedated). This study demonstrates that acepromazine sedation causes changes in MLAEP