Half-body radiotherapy in the treatment of canine lymphoma

In a Phase I–II study, half‐body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1989-04, Vol.3 (2), p.102-108
Main Authors: Laing, E.J. (Ontario Veterinary College, Guelph, Ontario), Fitzpatrick, P.J, Binnington, A.G, Norris, A.M, Mosseri, A, Rider, W.D, Valli, V.E, Baur, A
Format: Article
Language:English
Subjects:
Animals
CHIEN
Dog Diseases - radiotherapy
DOGS
EFECTOS SECUNDARIOS
EFFET SECONDAIRE
Evaluation Studies as Topic
Female
LINFOMA
LYMPHOMA
Lymphoma - radiotherapy
Lymphoma - veterinary
LYMPHOME
Male
PERRO
RADIACIONES
RADIATION
RADIATIONS
Remission Induction
SIDE EFFECTS
TERAPIA
THERAPEUTIQUE
THERAPY
Whole-Body Irradiation - methods
Whole-Body Irradiation - veterinary
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Summary:In a Phase I–II study, half‐body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs, 11 (79%) had a measurable decrease in tumor size. Five dogs achieved a complete or partial remission with a mean duration of 102 and 54 days, respectively. In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy‐resistant tumors.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1989.tb03087.x