Changing mortality for motor neuron disease in France (1968—2007): an age-period-cohort analysis

• Published in: European journal of epidemiology 2011-09, Vol.26 (9), p.729-737
• Main Authors: Gordon, Paul H., Artaud, Fanny, Aouba, Albertine, Laurent, Françoise, Meininger, Vincent, Elbaz, Alexis
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Age groups; Aged; Aged, 80 and over; Amyotrophic lateral sclerosis; Biological and medical sciences; Cardiology; Cohort effect; Cohort Studies; Death; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Degrees of freedom; Environmental changes; Environmental risk; Epidemiology; European Continental Ancestry Group - statistics & numerical data; Female; France - epidemiology; General aspects; Humans; Infectious Diseases; Male; Medical sciences; Medicine; Medicine & Public Health; Men; Middle Aged; Miscellaneous; Models, Statistical; Mortality; Mortality - trends; Motor neuron disease; Motor Neuron Disease - mortality; NEURO-EPIDEMIOLOGY; Neurology; Oncology; Population statistics; Population Surveillance; Public Health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk Assessment; Risk Factors; Sex Distribution; Sex Factors; Time Factors
• ISSN: 0393-2990; 1573-7284
• DOI: 10.1007/s10654-011-9595-0

The incidence and mortality of motor neuron disease (MND) increase with age and appear to have increased with time. The examination of period and cohort effects using age-period-cohort (APC) models can help characterize temporal trends. Our objective was to describe mortality from MND in France (1968-2007), and to examine the role of age, period of death, and birth-cohort on changes in mortality. The number of people who died from MND and population statistics (1968-2007) were extracted from French national records. Annual standardized (age/sex) mortality ratios (SMRs) were computed. Using Poisson regression, APC models examined the relationship between mortality rates and age, period of death, and birth-cohort in subjects aged 40-89 years. Deviance/degrees-of-freedom ratios evaluated model fit; ratios close to one indicated adequate fit. Between 1968 and 2007, 38,863 individuals died from MND (mortality rate = 1.74/100,000); 37,624 were aged 40—89 years. SMRs increased from 54 (95% CI = 49-59) in 1968 to 126 (120-132) in 2007. Male-to-female ratios declined from 1.80 in 1968 to 1.45 in 2007. Changing mortality rates were best explained by cohort effects (deviance/degrees-offreedom = 1.09). The relative risk of dying from MND increased markedly for persons born between 1880 and 1920, and more slowly after 1920. In conclusion, mortality rates for MND increased between 1968 and 2007, and more rapidly in women than men. This increase was better explained by the birth-cohort of individuals than by period effects. Changing environmental exposures may be a possible explanation and these findings warrant the continued search for environmental risk factors for MND.