Current Topics in DNA Double-Strand Break Repair

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins...

Full description

Saved in:
Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 2008-03, Vol.49 (2), p.93-103
Main Authors: Kobayashi, Junya, Iwabuchi, Kuniyoshi, Miyagawa, Kiyoshi, Sonoda, Eiichiro, Suzuki, Keiji, Takata, Minoru, Tauchi, Hiroshi
Format: Article
Language:English
Subjects:
Analysis
Cell Cycle Proteins - physiology
DNA
DNA Breaks, Double-Stranded - radiation effects
DNA Repair - physiology
DNA-Binding Proteins - physiology
Endonucleases - physiology
Histones - physiology
Humans
Ionizing radiation
Nuclear Proteins - physiology
Proteins
Signal Transduction - physiology
Ubiquitin-Conjugating Enzymes - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed. 1. INTRODUCTION：AT the broken DNA ends Ionizing radiation (IR) induces a variety of DNA lesions, including single- and double-strand breaks, DNA-protein cross-links, and various base damages. A DNA doublestrand break (DSB) is one of the most serious threats to cells because it can result in loss or rearrangement of genetic information, leading to cell death or carcinogenesis. There are at least two repair pathways which can repair DSBs: (1) non-homologous end-joining (NHEJ)- and/or microhomology-mediated recombination, and (2) homologous recombination (HR)-mediated repair.1)
ISSN:0449-3060
1349-9157
1349-9157
DOI:10.1269/jrr.07130