Brain Diffusivity in Infants With Hypoxic–Ischemic Encephalopathy Following Whole Body Hypothermia: Preliminary Results

Hypoxic–ischemic encephalopathy is an important cause of neuropsychological deficits. Little is known about brain diffusivity in these infants following cooling and its potential in predicting outcome. Diffusion tensor imaging was applied to 3 groups: (1) three infants with hypoxic–ischemic encephal...

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Bibliographic Details
Published in:Journal of child neurology 2011-10, Vol.26 (10), p.1230-1236
Main Authors: Artzi, Moran, Sira, Liat Ben, Bassan, Haim, Gross-Tsur, Varda, Berger, Irit, Marom, Ronella, Leitner, Yael, Bental, Yoram, Shiff, Yakov, Geva, Ronny, Weinstein, Maya, Bashat, Dafna Ben
Format: Article
Language:English
Subjects:
Age Factors
Apgar Score
Brain - pathology
Diffusion Tensor Imaging
Female
Follow-Up Studies
Humans
Hypothermia, Induced - adverse effects
Hypoxia-Ischemia, Brain - therapy
Infant
Male
Neurologic Examination
Treatment Outcome
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Summary:Hypoxic–ischemic encephalopathy is an important cause of neuropsychological deficits. Little is known about brain diffusivity in these infants following cooling and its potential in predicting outcome. Diffusion tensor imaging was applied to 3 groups: (1) three infants with hypoxic–ischemic encephalopathy: cooled; (2) three infants with hypoxic–ischemic encephalopathy: noncooled; and (3) four controls. Diffusivity values at the corticospinal tract, thalamus, and putamen were correlated with Apgar scores and early neurodevelopmental outcome. While cooled infants exhibited lower Apgar scores than noncooled infants, their developmental scores at a mean age of 8 months were higher. All groups differed in their diffusivity values with the cooled infants showing better values compared with the noncooled, correlating with early neurodevelopmental outcome. These preliminary results indicate that diffusion tensor imaging performed at an early age in infants with hypoxic–ischemic encephalopathy may forecast clinical outcome and support the neuroprotective effect of hypothermia treatment.
ISSN:0883-0738
1708-8283
DOI:10.1177/0883073811402346