Cognitive dysfunction in SLE: development of a screening tool

Background. Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessm...

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Bibliographic Details
Published in:Lupus 2011-10, Vol.20 (11), p.1142-1146
Main Authors: Adhikari, T, Piatti, A, Luggen, M
Format: Article
Language:English
Subjects:
Adult
African Americans
Automation
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognitive ability
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - etiology
Disease
Female
Geriatrics
Humans
Immunology
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - psychology
Male
Mental disorders
Middle Aged
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Reproducibility of Results
Rheumatology
Systemic lupus erythematosus
White people
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Summary:Background. Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). Both are time-consuming and neither is readily available for screening purposes. Purpose. The aim of our study was to evaluate the Montreal Cognitive Assessment (MoCA) test as a screening tool for detection of CD in SLE. Methods. SLE patients fulfilling ACR criteria were administered the ANAM, a computerized test battery which measures various cognitive domains and the MoCA, a one-page, performance-based screening test designed to detect mild cognitive impairment in the elderly. With the ANAM as the gold standard, the performance characteristics of the MoCA were assessed. Results. In total, 44 patients were evaluated. Of these, 11 (25%) were identified by the ANAM as being impaired in comparison with 13 (29.5%) by the MoCA. The scores were significantly correlated (r = 0.57, p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203311405374