The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

Abstract Superparamagnetic iron oxide (SPIO) nanoparticles are very useful in cell imaging; meanwhile, however, biosafety concerns associated with their use, especially on therapeutic stem cells, have arisen. Most studies of biosafety issues focus on whether the nanoparticles have deleterious effect...

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Bibliographic Details
Published in:Biomaterials 2009-08, Vol.30 (22), p.3645-3651
Main Authors: Huang, Dong-Ming, Hsiao, Jong-Kai, Chen, Ying-Chun, Chien, Li-Ying, Yao, Ming, Chen, Yin-Kai, Ko, Bor-Sheng, Hsu, Szu-Chun, Tai, Lin-Ai, Cheng, Hui-Ying, Wang, Shih-Wei, Yang, Chung-Shi, Chen, Yao-Chang
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biocompatibility
Cell Cycle - physiology
Cell proliferation
Cell Proliferation - drug effects
Contrast Media - chemistry
Contrast Media - pharmacology
Dentistry
Dextrans
Ferric Compounds - chemistry
Ferric Compounds - pharmacology
Ferrosoferric Oxide
Humans
Hydrogen Peroxide - metabolism
Iron - chemistry
Iron - pharmacology
Magnetic Resonance Imaging
Magnetics
Magnetite Nanoparticles
Materials Testing
Mesenchymal stem cell
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - drug effects
Mesenchymal Stromal Cells - physiology
MRI
Nanoparticle
Nanoparticles - chemistry
Oxidants - metabolism
Oxidation-Reduction
Oxides - chemistry
Oxides - pharmacology
Peroxidases - metabolism
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Summary:Abstract Superparamagnetic iron oxide (SPIO) nanoparticles are very useful in cell imaging; meanwhile, however, biosafety concerns associated with their use, especially on therapeutic stem cells, have arisen. Most studies of biosafety issues focus on whether the nanoparticles have deleterious effects. Here, we report that Ferucarbotran, an ionic SPIO, is not toxic to human mesenchymal stem cells (hMSCs) under the conditions of these experiments but instead increases cell growth. Ferucarbotran-promoted cell growth is due to its ability to diminish intracellular H2 O2 through intrinsic peroxidase-like activity. Also, Ferucarbotran can accelerate cell cycle progression, which may be mediated by the free iron (Fe) released from lysosomal degradation and involves the alteration of Fe on the expression of the protein regulators of the cell cycle.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2009.03.032