Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis

Objective To summarize the evidence on short-, mid-, and long-term results up to 5 years of uterine artery embolization in comparison to surgery. Study Design We searched the CENTRAL, MEDLINE and EMBASE databases for randomized clinical trials comparing uterine artery embolization with hysterectomy/...

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Published in:American journal of obstetrics and gynecology 2011-10, Vol.205 (4), p.317.e1-317.e18
Main Authors: van der Kooij, Sanne M., MD, Bipat, Shandra, PhD, Hehenkamp, Wouter J.K., MD, PhD, Ankum, Willem M., MD, PhD, Reekers, Jim A., MD, PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
embolization
Female
fibroids
Gynecology. Andrology. Obstetrics
heavy menstrual bleeding
Humans
hysterectomy
Leiomyoma - surgery
Leiomyoma - therapy
Medical sciences
myomas
Obstetrics and Gynecology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Uterine Artery Embolization
Uterine Neoplasms - surgery
Uterine Neoplasms - therapy
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Summary:Objective To summarize the evidence on short-, mid-, and long-term results up to 5 years of uterine artery embolization in comparison to surgery. Study Design We searched the CENTRAL, MEDLINE and EMBASE databases for randomized clinical trials comparing uterine artery embolization with hysterectomy/myomectomy in premenopausal women with heavy menstrual bleeding caused by symptomatic uterine fibroids, written from September 1995 to November 2010. Two reviewers independently assessed methodologic quality and extracted data from included trials. Results Four randomized controlled trials with a total of 515 patients were included. On the short-term, uterine artery embolization showed fewer blood loss, shorter hospital stay, and quicker resumption of work. Mid- and long-term results showed comparable health-related quality of life results and a higher reintervention rate in the uterine artery embolization group, whereas both groups were equally satisfied. Conclusion Uterine artery embolization has short-term advantages over surgery. On the mid- and long-term the benefits were similar, except for a higher reintervention rate after uterine artery embolization.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2011.03.016