Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection

Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection and comparative analysis with S1P administration. [Display omitted] ► LPA as possible therapeutic molecule in MTB infection. ► LPA reduces pulmonary CFUs and histopathology in MTB in...

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Published in:Cellular immunology 2011, Vol.271 (1), p.1-4
Main Authors: Delogu, Giovanni, Sali, Michela, Rocca, Stefano, Quintiliani, Gianluca, Santucci, Marilina B., Greco, Emanuela, Cabibbo, Andrea, Mariani, Francesca, Colizzi, Vittorio, Fadda, Giovanni, Fraziano, Maurizio
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Colony Count, Microbial
Female
Innate immunity
Lung - drug effects
Lung - immunology
Lung - microbiology
Lysophosphatidic acid
Lysophospholipids - immunology
Lysophospholipids - pharmacology
Mice
Mice, Inbred BALB C
Mycobacterium
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - growth & development
Mycobacterium tuberculosis - immunology
Primary infection
Sphingosine - analogs & derivatives
Sphingosine - immunology
Sphingosine - pharmacology
Time Factors
Treatment Outcome
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - pathology
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Summary:Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection and comparative analysis with S1P administration. [Display omitted] ► LPA as possible therapeutic molecule in MTB infection. ► LPA reduces pulmonary CFUs and histopathology in MTB infected mice during primary infection but not during acute disease. ► LPA as a molecule enhancing antimycobacterial innate immunity. Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2011.05.014