A Pd-mediated new strategy to functionalized 2-aminochromenes: Their in vitro evaluation as potential anti tuberculosis agents

A multi component based synthesis involving palladium catalyzed C–C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new c...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2011-11, Vol.21 (21), p.6433-6439
Main Authors: Ram Reddy, T., Srinivasula Reddy, L., Rajeshwar Reddy, G., Nuthalapati, Venkata Subbaiah, Lingappa, Y., Sandra, Sandhya, Kapavarapu, Ravikumar, Misra, Parimal, Pal, Manojit
Format: Article
Language:English
Subjects:
2-Aminochromenes
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Benzopyrans - chemistry
Benzopyrans - pharmacology
Biological and medical sciences
Chorismate mutase
Drug Evaluation, Preclinical
in vitro studies
In Vitro Techniques
Inhibitory Concentration 50
Medical sciences
Models, Molecular
Multi-component reactions (MCRs)
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Palladium
Palladium - chemistry
Pharmacology. Drug treatments
tuberculosis
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Summary:A multi component based synthesis involving palladium catalyzed C–C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new compound library. Many of these compounds showed Mycobacterium tuberculosis H37Rv chorismate mutase inhibiting properties in vitro representing the lead example of chorismate mutase inhibition by heteroarene based compounds.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.08.088