Fine Tuning Micellar Core-Forming Block of Poly(ethylene glycol)-block-poly(ε-caprolactone) Amphiphilic Copolymers Based on Chemical Modification for the Solubilization and Delivery of Doxorubicin

This study aimed to optimize poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL)-based amphiphilic block copolymers for achieving a better micellar drug delivery system (DDS) with improved solubilization and delivery of doxorubicin (DOX). First, the Flory–Huggins interaction parameters between...

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Bibliographic Details
Published in:Biomacromolecules 2011-07, Vol.12 (7), p.2562-2572
Main Authors: Yan, Jinliang, Ye, Zhaoyang, Chen, Min, Liu, Zhanzhan, Xiao, Yan, Zhang, Yan, Zhou, Yan, Tan, Wensong, Lang, Meidong
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Cell Survival - drug effects
Dose-Response Relationship, Drug
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug Delivery Systems
Exact sciences and technology
General pharmacology
Humans
Lactones - chemistry
Lactones - pharmacology
Medical sciences
Micelles
Molecular Structure
Organic polymers
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Polymers with particular properties
Preparation, kinetics, thermodynamics, mechanism and catalysts
Solubility
Structure-Activity Relationship
Surface Properties
Tissue Distribution
Tumor Cells, Cultured
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