Minor Histocompatibility Antigens as Risk Factor for Poor Prognosis in Kidney Transplantation

Abstract Progress in transplantation has relied on similar human leukocyte antigen (HLA) matching between the donor and the patient, while the role of other immunologic factors like non-HLA markers including minor histocompatibility antigens (miHA) are currently in the forefront. miHA are polymorphi...

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Bibliographic Details
Published in:Transplantation proceedings 2011-11, Vol.43 (9), p.3319-3323
Main Authors: Pabón, M.A, Navarro, C.E, Martin, R, Rodríguez, M, Martin, I, Gaitán, L, Gómez, A, Lozano, E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Epidemiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Graft Rejection
Graft Survival
Graft vs Host Disease - immunology
H-Y Antigen - immunology
Histocompatibility - immunology
Histocompatibility Antigens Class I - metabolism
Histocompatibility Testing
Humans
Kidney Transplantation - methods
Medical sciences
Mice
Minor Histocompatibility Antigens - immunology
Minor Histocompatibility Antigens - metabolism
Prognosis
Public health. Hygiene
Public health. Hygiene-occupational medicine
Renal Insufficiency, Chronic - therapy
Risk Factors
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Progress in transplantation has relied on similar human leukocyte antigen (HLA) matching between the donor and the patient, while the role of other immunologic factors like non-HLA markers including minor histocompatibility antigens (miHA) are currently in the forefront. miHA are polymorphic proteins that vary even in monozygotic twins. The best known is the H-Y antigen, but there are also other autosomal miHA and MICA (MHC class I chain-related gene A). miHA have been well studied in transplantation of hematopoietic precursors, but not in solid organ transplantation. The most important studies in this field relate to incompatibility of H-Y antigen as a risk factor in kidney transplantation, although the findings are still inconclusive. This review presents the role of minor histocompatibility antigens in solid organ transplantation, especially of the kidney.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.09.007