Effects of Astaxanthin on Oxidative Stress in Overweight and Obese Adults

Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, d...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2011-12, Vol.25 (12), p.1813-1818
Main Authors: Choi, Hye Duck, Kim, Ji Hae, Chang, Min Jung, Kyu-Youn, Yeo, Shin, Wan Gyoon
Format: Article
Language:English
Subjects:
Adult
antioxidant
Antioxidants - pharmacology
astaxanthin
Biological and medical sciences
Biomarkers - blood
Diet
Double-Blind Method
Female
General pharmacology
Humans
Isoprostanes - analysis
lipid peroxidation
Lipid Peroxidation - drug effects
Male
Malondialdehyde - analysis
Medical sciences
Obesity - blood
Overweight - blood
overweight and obesity
oxidative stress
Oxidative Stress - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Prospective Studies
Superoxide Dismutase - analysis
Xanthophylls - administration & dosage
Xanthophylls - blood
Xanthophylls - pharmacology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxidative stress is caused by an imbalance between the antioxidant and the reactive oxygen species, which results in damage to cells or tissues. Recent studies have reported that oxidative stress is involved in obesity, in addition to many other human diseases and aging. A prospective, randomized, double‐blind study was performed to investigate the effect of astaxanthin (ASX), which is known to be a potent antioxidant, on oxidative stress in overweight and obese adults in Korea. Twenty‐three adults with BMI > 25.0 kg/m2 enrolled in this study and were randomly assigned to two dose groups: ASX 5 mg and 20 mg once daily for 3 weeks. Malondialdehyde (MDA), isoprostane (ISP), superoxide dismutase (SOD) and total antioxidant capacity (TAC), as oxidative stress biomarkers, were measured at baseline and 1, 2 and 3 weeks after ASX administration. Compared with baseline, the MDA (by 34.6% and 35.2%) and ISP (by 64.9% and 64.7%) levels were significantly lowered, whereas SOD (by 193% and 194%) and TAC (by 121% and 125%) levels were significantly increased in two dose groups after the 3 week intervention. This study revealed that supplemental ASX for 3 weeks improved oxidative stress biomarkers by suppressing lipid peroxidation and stimulating the activity of the antioxidant defense system. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.3494