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Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also show...
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| Published in: | Bioorganic & medicinal chemistry letters 2011-03, Vol.21 (6), p.1716-1718 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c507t-d2fe40f504929b1dc3adc6f6ebf0d35bd4d1217e9443983b3f5380451a897fd03 |
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| cites | cdi_FETCH-LOGICAL-c507t-d2fe40f504929b1dc3adc6f6ebf0d35bd4d1217e9443983b3f5380451a897fd03 |
| container_end_page | 1718 |
| container_issue | 6 |
| container_start_page | 1716 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 21 |
| creator | Cho, Jun-Young Kwon, Yun-Ju Sohn, Mi-Jin Seok, Soon-Ja Kim, Won-Gon |
| description | A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
M and also showed antibacterial activity against
S. aureus and MRSA.
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
μM and also showed antibacterial activity against
S. aureus and MRSA. |
| doi_str_mv | 10.1016/j.bmcl.2011.01.080 |
| format | article |
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Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
M and also showed antibacterial activity against
S. aureus and MRSA.
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
μM and also showed antibacterial activity against
S. aureus and MRSA.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2011.01.080</identifier><identifier>PMID: 21316961</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Antibacterial ; antibacterial properties ; Biological and medical sciences ; Catechols - pharmacology ; chemistry ; culture media ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) ; Enoyl-ACP reductase ; Enzyme Inhibitors - pharmacology ; Fungi - enzymology ; General pharmacology ; Hispidin ; Inhibitor ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Medical sciences ; medicinal fungi ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phellinus linteus ; Pyrones - pharmacology ; spectral analysis ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Infrared ; Staphylococcus aureus</subject><ispartof>Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1716-1718</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-d2fe40f504929b1dc3adc6f6ebf0d35bd4d1217e9443983b3f5380451a897fd03</citedby><cites>FETCH-LOGICAL-c507t-d2fe40f504929b1dc3adc6f6ebf0d35bd4d1217e9443983b3f5380451a897fd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23965654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21316961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Jun-Young</creatorcontrib><creatorcontrib>Kwon, Yun-Ju</creatorcontrib><creatorcontrib>Sohn, Mi-Jin</creatorcontrib><creatorcontrib>Seok, Soon-Ja</creatorcontrib><creatorcontrib>Kim, Won-Gon</creatorcontrib><title>Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
M and also showed antibacterial activity against
S. aureus and MRSA.
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
μM and also showed antibacterial activity against
S. aureus and MRSA.</description><subject>Antibacterial</subject><subject>antibacterial properties</subject><subject>Biological and medical sciences</subject><subject>Catechols - pharmacology</subject><subject>chemistry</subject><subject>culture media</subject><subject>Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)</subject><subject>Enoyl-ACP reductase</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fungi - enzymology</subject><subject>General pharmacology</subject><subject>Hispidin</subject><subject>Inhibitor</subject><subject>Inhibitory Concentration 50</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>medicinal fungi</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phellinus linteus</subject><subject>Pyrones - pharmacology</subject><subject>spectral analysis</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spectrophotometry, Infrared</subject><subject>Staphylococcus aureus</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkU-LFDEQxYMo7uzqF_CguYgXe6x0_kwH9rIMrgoLLuiCt5BOKjsZetJr0q3MtzfDjHpTKJI6_Kry8h4hLxgsGTD1brvsd25YtsDYEmp18IgsmFCi4QLkY7IAraDptPh2Rs5L2QIwAUI8JWct40xpxRZkc7vBYYipTHaK6S21NOFPGtMm9nEaMx0DxTTuh-ZqfUsz-tlNtiB9yGNt0dN-T6cN0h366GKyAw1zup8LPa2tXT0nnMsz8iTYoeDz031B7q7ff11_bG4-f_i0vrppnITV1Pg2oIAgQehW98w7br1TQWEfwHPZe-FZy1aoheC64z0PkncgJLOdXgUP_IK8Oe6tEr_PWCazi8VVMTbhOBejYcVkWyf-S3ZSagYKVpVsj6TLYykZg3nIcWfz3jAwhyjM1hyiMIcoDNTqDkJentbPfbXnz8hv7yvw-gTY4uwQsk0ulr8c10oqKSr36sgFOxp7nytz96W-JGueXNS_VOLySGA19kfEbIqLmGo-MaObjB_jv5T-Ag-KsHs</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Cho, Jun-Young</creator><creator>Kwon, Yun-Ju</creator><creator>Sohn, Mi-Jin</creator><creator>Seok, Soon-Ja</creator><creator>Kim, Won-Gon</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20110315</creationdate><title>Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus</title><author>Cho, Jun-Young ; Kwon, Yun-Ju ; Sohn, Mi-Jin ; Seok, Soon-Ja ; Kim, Won-Gon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-d2fe40f504929b1dc3adc6f6ebf0d35bd4d1217e9443983b3f5380451a897fd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antibacterial</topic><topic>antibacterial properties</topic><topic>Biological and medical sciences</topic><topic>Catechols - pharmacology</topic><topic>chemistry</topic><topic>culture media</topic><topic>Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)</topic><topic>Enoyl-ACP reductase</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fungi - enzymology</topic><topic>General pharmacology</topic><topic>Hispidin</topic><topic>Inhibitor</topic><topic>Inhibitory Concentration 50</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>medicinal fungi</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phellinus linteus</topic><topic>Pyrones - pharmacology</topic><topic>spectral analysis</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spectrophotometry, Infrared</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Jun-Young</creatorcontrib><creatorcontrib>Kwon, Yun-Ju</creatorcontrib><creatorcontrib>Sohn, Mi-Jin</creatorcontrib><creatorcontrib>Seok, Soon-Ja</creatorcontrib><creatorcontrib>Kim, Won-Gon</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Jun-Young</au><au>Kwon, Yun-Ju</au><au>Sohn, Mi-Jin</au><au>Seok, Soon-Ja</au><au>Kim, Won-Gon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2011-03-15</date><risdate>2011</risdate><volume>21</volume><issue>6</issue><spage>1716</spage><epage>1718</epage><pages>1716-1718</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
M and also showed antibacterial activity against
S. aureus and MRSA.
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus
Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited
Staphylococcus aureus enoyl-ACP reductase with an IC
50 of 6
μM and also showed antibacterial activity against
S. aureus and MRSA.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>21316961</pmid><doi>10.1016/j.bmcl.2011.01.080</doi><tpages>3</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1716-1718 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Antibacterial antibacterial properties Biological and medical sciences Catechols - pharmacology chemistry culture media Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) Enoyl-ACP reductase Enzyme Inhibitors - pharmacology Fungi - enzymology General pharmacology Hispidin Inhibitor Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Medical sciences medicinal fungi Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phellinus linteus Pyrones - pharmacology spectral analysis Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Staphylococcus aureus |
| title | Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus |
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