In vitro antiviral activity against herpes simplex virus in the abalone Haliotis laevigata

As viruses are extremely abundant in oceans, marine organisms may have evolved novel metabolites to protect themselves from viral infection. This research examined a well-known commercial gastropod, abalone (Haliotidae), which in Australia have recently experienced disease due to a neurotropic infec...

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Bibliographic Details
Published in:Journal of general virology 2011-03, Vol.92 (Pt 3), p.627-637
Main Authors: DANG, Vinh T, BENKENDORFFT, Kirsten, SPECK, Peter
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Antiviral Agents - toxicity
Biological and medical sciences
Cell Extracts - isolation & purification
Cell Extracts - pharmacology
Cell Extracts - toxicity
Cell Survival
Cercopithecus aethiops
Digestive System - chemistry
Fundamental and applied biological sciences. Psychology
Gastropoda
Gastropoda - chemistry
Haliotidae
Haliotis
Haliotis laevigata
Hemolymph - chemistry
Herpes simplex virus 1
Herpesvirus
Herpesvirus 1, Human - drug effects
Marine
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Vero Cells
Viral Plaque Assay
Virology
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Summary:As viruses are extremely abundant in oceans, marine organisms may have evolved novel metabolites to protect themselves from viral infection. This research examined a well-known commercial gastropod, abalone (Haliotidae), which in Australia have recently experienced disease due to a neurotropic infection, abalone viral ganglioneuritis, caused by an abalone herpesvirus (AbHV). Due to the lack of molluscan cell lines for culturing AbHV, the antiviral activity of the abalone Haliotis laevigata was assessed against another neurotropic herpesvirus, herpes simplex virus type 1 (HSV-1), using a plaque assay. The concentration range at which abalone extract was used for antiviral testing caused minimal (
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.025247-0