Transient Ischemic Attack and Acute Ischemic Stroke: Associations With Retinal Microvascular Signs

Small vessel disease plays a role in cerebral events. We aimed to investigate the prevalence and patterns of retinal microvascular signs (surrogates for cerebral small vessel disease) among patients with transient ischemic attack (TIA) or acute stroke and population control subjects. Patients with T...

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Bibliographic Details
Published in:Stroke (1970) 2011-02, Vol.42 (2), p.404-408
Main Authors: JIE JIN WANG, BAKER, Michelle L, HAND, Peter J, HANKEY, Graeme J, LINDLEY, Richard I, ROCHTCHINA, Elena, WONG, Tien Y, LIEW, Gerald, MITCHELL, Paul
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Female
Humans
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - pathology
Male
Medical sciences
Microcirculation - physiology
Middle Aged
Neurology
Pharmacology. Drug treatments
Retinal Diseases - etiology
Retinal Diseases - pathology
Risk Factors
Stroke - complications
Stroke - pathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Small vessel disease plays a role in cerebral events. We aimed to investigate the prevalence and patterns of retinal microvascular signs (surrogates for cerebral small vessel disease) among patients with transient ischemic attack (TIA) or acute stroke and population control subjects. Patients with TIA or acute stroke aged ≥49 years admitted to hospitals in Melbourne and Sydney, Australia, were recruited to the Multi-Centre Retina and Stroke Study (n=693, 2005 to 2007). Control subjects were Blue Mountains Eye Study participants aged ≥49 years without TIAs or stroke (n=3384, 1992 to 1994, west of Sydney). TIA, ischemic stroke, or primary intracerebral hemorrhage was classified using standardized neurological assessments, including neuroimaging. Retinal microvascular signs (retinopathy, focal arteriolar narrowing, arteriovenous nicking, enhanced arteriolar light reflex) were assessed from retinal photographs masked to clinical information. Patients with TIA or acute stroke were older than control subjects and more likely to have stroke risk factors. After adjustment for study site and known risk factors, all retinal microvascular signs were more common in patients with TIA or acute stroke than in control subjects (OR, 1.9 to 8.7; P
ISSN:0039-2499
1524-4628
1524-4628
DOI:10.1161/STROKEAHA.110.598599