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Monoclonal Antibodies and Progressive Multifocal Leukoencephalopathy

Monoclonal antibodies have become an important treatment option for a number of serious conditions. Concerns have arisen about the potential association of these products with progressive multifocal leukoencephalopathy (PML). A list of monoclonal antibodies authorized for sale was derived from the H...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2011-07, Vol.38 (4), p.565-571
Main Authors: Keene, Daniel L., Legare, Carole, Taylor, Elaine, Gallivan, Jim, Cawthorn, Gloria Mah, Vu, Duc
Format: Article
Language:English
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Summary:Monoclonal antibodies have become an important treatment option for a number of serious conditions. Concerns have arisen about the potential association of these products with progressive multifocal leukoencephalopathy (PML). A list of monoclonal antibodies authorized for sale was derived from the Health Canada Drug Product Database. Case reports of PML after exposure to a monoclonal antibody authorized for use in Canada were retrieved by searching Canada Vigilance and WHO adverse event databases and through a Pub MED/Medline literature search. 182 adverse event case reports were retrieved (adalimumab -1 case, alemtuzumab-14, bevacizumab -3, cetuximab -1, efalizumab - 8, ibritumomab tiuxetan-5, infliximab-4, natalizumab-32, and rituximab-114). The Canadian Product Monographs for natalizumab and ritiximab contain box warnings for PML. A natalizumab registry has been established.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100012105