Intermittent Preventive Treatment during Pregnancy with Sulphadoxine-Pyrimethamine May Promote Plasmodium falciparum Gametocytogenesis

Objectives: To determine the incidence of gametocytes and the propensity of sulphadoxine-pyrimethamine to promote gametocytogenesis when used as intermittent preventive treatment in pregnancy. Subjects and Methods: This observational non-interventional study assessed the influence of intermittent pr...

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Bibliographic Details
Published in:Medical principles and practice 2012, Vol.21 (1), p.63-67
Main Authors: Fehintola, F.A., Balogun, S.T., Adeoye, S.B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antimalarials - administration & dosage
Antimalarials - adverse effects
Chi-Square Distribution
Drug Combinations
Drug Therapy, Combination
Female
Gametogenesis - drug effects
Geography
Humans
Incidence
Malaria - drug therapy
Mosquito Nets
Nigeria
Original Paper
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Pregnancy
Pregnancy Complications, Parasitic - prevention & control
Pyrimethamine - adverse effects
Risk Factors
Statistics as Topic
Sulfadoxine - adverse effects
Time Factors
Young Adult
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Summary:Objectives: To determine the incidence of gametocytes and the propensity of sulphadoxine-pyrimethamine to promote gametocytogenesis when used as intermittent preventive treatment in pregnancy. Subjects and Methods: This observational non-interventional study assessed the influence of intermittent preventive treatment with sulphadoxine-pyrimethamine on Plasmodium falciparum gametocytaemia among Nigerian pregnant women. A total of 306 pregnant women were enrolled in the study. Results: The 306 pregnant women had 711 events, of which 31 pure gametocytaemic episodes were documented and 27 were recorded among the intermittent preventive treatment users. Only 4 episodes of pure gametocytaemia were recorded in pregnant women who did not receive any dose of sulphadoxine-pyrimethamine (27/129 vs. 4/276, χ 2 = 15.9, p = 0.00006). Conclusion: Our findings show that intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine may predispose to gametocyte carriage in pregnant women resident in the hyperendemic malaria region of southwest Nigeria. We therefore suggest that the use of insecticide-treated nets be encouraged among pregnant women resident in malaria-endemic sub-Saharan Africa in order to reduce malaria transmission.
ISSN:1011-7571
1423-0151
DOI:10.1159/000332405