Large-scale genome projects enter the clinic on both sides of the Atlantic

Genetic testing has become more common in cancer care in recent years. However, nearly all such tests are limited to a few genetic alterations that affect patient responses to targeted agents. Now, several groups are working to expand that approach to more patients and more genes, including many wit...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2011-12, Vol.103 (23), p.1730-1731
Main Author: Tuma, Rabiya S
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Biomarkers, Tumor - genetics
Cancer
Cancer Care Facilities
Class I Phosphatidylinositol 3-Kinases
Drug Industry - trends
Genetic testing
Genetic Testing - methods
Genome, Human - genetics
Genotype
Human Genome Project
Humans
Molecular Targeted Therapy
Mutation
National Health Programs
Neoplasms - drug therapy
Neoplasms - genetics
Netherlands
Patients
Phosphatidylinositol 3-Kinases - genetics
Receptor, Epidermal Growth Factor - genetics
Sequence Analysis, DNA - methods
United Kingdom
United States
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Summary:Genetic testing has become more common in cancer care in recent years. However, nearly all such tests are limited to a few genetic alterations that affect patient responses to targeted agents. Now, several groups are working to expand that approach to more patients and more genes, including many with unknown function or import. Earlier this hill, researchers launched two programs designed to offer genetic testing to thousands of patients in routine care. Cancer Research UK is running one program, and Dana-Farber Cancer institute and Brigham and Women's Hospital in Boston are running the other. Together, the projects will probably speed uptake of genetic testing in regular cancer care, as well as provide the raw data that researchers need for future drug development and improved interventions.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djr503