Surface Modification with Poly(sulfobetaine methacrylate-co-acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation

Zwitterionic sulfobetaine methacrylate (SBMA) polymers were known to possess excellent antifouling properties due to high hydration capacity and neutral charge surface. In this study, copolymers of SBMA and acrylic acid (AA) with a variety of compositions were synthesized and were immobilized onto p...

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Bibliographic Details
Published in:Biomacromolecules 2011-12, Vol.12 (12), p.4348-4356
Main Authors: Kuo, Wei-Hsuan, Wang, Meng-Jiy, Chien, Hsiu-Wen, Wei, Ta-Chin, Lee, Chiapyng, Tsai, Wei-Bor
Format: Article
Language:English
Subjects:
Acrylates - chemical synthesis
Acrylates - metabolism
Adsorption
Applied sciences
Biocompatible Materials - chemistry
Biological properties
Blood Coagulation - physiology
Blood Platelets - metabolism
Exact sciences and technology
Fibrinogen - metabolism
Hydrogen-Ion Concentration
Materials Testing
Methacrylates - chemical synthesis
Methacrylates - metabolism
Organic polymers
Physicochemistry of polymers
Platelet Adhesiveness - physiology
Polymers - metabolism
Properties and characterization
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Summary:Zwitterionic sulfobetaine methacrylate (SBMA) polymers were known to possess excellent antifouling properties due to high hydration capacity and neutral charge surface. In this study, copolymers of SBMA and acrylic acid (AA) with a variety of compositions were synthesized and were immobilized onto polymeric substrates with layer-by-layer polyelectrolyte films via electrostatic interaction. The amounts of platelet adhesion and fibrinogen adsorption were determined to evaluate hemocompatibility of poly­(SBMA-co-AA)-modified substrates. Among various deposition conditions by modulating SBMA ratio in the copolymers and pH of the deposition solution, poly­(SBMA56-co-AA44) deposited at pH 3.0 possessed the best hemocompatibility. This work demonstrated that poly­(SBMA-co-AA) copolymers adsorbed on polyelectrolyte-base films via electrostatic interaction improve hemocompatibility effectively and are applicable for various substrates including TCPS, PU, and PDMS. Furthermore, poly­(SBMA-co-AA)-coated substrate possesses great durability under rigorous conditions. The preliminary hemocompatibility tests regarding platelet adhesion, fibrinogen adsorption, and plasma coagulation suggest the potential of this technique for the application to blood-contacting biomedical devices.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm2013185