Application of the Multisolute Osmotic Virial Equation to Solutions Containing Electrolytes

• Published in: The journal of physical chemistry. B 2011-12, Vol.115 (49), p.14531-14543
• Main Authors: Prickett, Richelle C, Elliott, Janet A.W, McGann, Locksley E
• Format: Article
• Language: English
• Subjects: Algorithms; Aqueous solutions; B: Statistical Mechanics, Thermodynamics, Medium Effects; Dimethyl sulfoxide; Dimethyl Sulfoxide - chemistry; Electrolytes; Electrolytes - chemistry; Empirical equations; Glycerol - chemistry; Glycerols; Mathematical analysis; Sodium chloride; Sodium Chloride - chemistry; Solutions - chemistry; Starches
• ISSN: 1520-6106; 1520-5207
• DOI: 10.1021/jp206011m

The prediction of multisolute solution behavior of solutions containing electrolytes is important in many areas of research, including cryopreservation. In this study, the use of a novel form of the osmotic virial equation for multisolute solutions containing an electrolyte is investigated and compared to a rigorous electrolyte solution theory, the Pitzer–Debye–Huckel equation. For aqueous solutions containing a small molecule (either dimethyl sulfoxide or glycerol) and sodium chloride, the multisolute osmotic virial equation, which utilizes only two parameters to capture the electrolyte solution behavior, is shown to be as accurate as the Pitzer–Debye–Huckel equation, which utilizes six empirical parameters and multiple functions to capture the electrolyte solution behavior. In addition, an approach based on the multisolute osmotic virial equation to investigate the effect of electrolyte concentration on macromolecule solution behavior is presented and applied to aqueous solutions of hydroxyethyl starch and sodium chloride. The multisolute osmotic virial equation is shown to be an accurate, straightforward predictive solution theory for important multisolute solutions containing electrolytes.