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Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cel...
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| Published in: | Science (American Association for the Advancement of Science) 2011-12, Vol.334 (6061), p.1420-1424 |
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| cites | cdi_FETCH-LOGICAL-c482t-5a09f3050c255f20514b2ddf911be14e2a73cc16226621c0ad5edada03cde1b83 |
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| container_issue | 6061 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 334 |
| creator | Takeda, Norifumi Jain, Rajan LeBoeuf, Matthew R. Wang, Qiaohong Lu, Min Min Epstein, Jonathan A. |
| description | Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches. |
| doi_str_mv | 10.1126/science.1213214 |
| format | article |
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Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1213214</identifier><identifier>PMID: 22075725</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Cell Cycle ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cells ; Cells, Cultured ; Crypts ; Cultured cells ; Descendants ; Endocrine cells ; Epithelial cells ; Epithelial Cells - cytology ; Fundamental and applied biological sciences. Psychology ; Homeodomain Proteins - analysis ; Homeodomain Proteins - genetics ; Intestinal Mucosa - cytology ; Intestinal Mucosa - drug effects ; Intestine, Small - cytology ; Intestine, Small - drug effects ; Intestine. Mesentery ; Intestines ; Mice ; Models, Biological ; Multipotent Stem Cells - cytology ; Multipotent Stem Cells - physiology ; Neural stem cells ; Organoids ; Paneth Cells - cytology ; Stem Cell Niche ; Stem cells ; Tamoxifen - pharmacology ; Vertebrates: digestive system</subject><ispartof>Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6061), p.1420-1424</ispartof><rights>Copyright © 2011 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-5a09f3050c255f20514b2ddf911be14e2a73cc16226621c0ad5edada03cde1b83</citedby><cites>FETCH-LOGICAL-c482t-5a09f3050c255f20514b2ddf911be14e2a73cc16226621c0ad5edada03cde1b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2882,2883,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25376388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22075725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeda, Norifumi</creatorcontrib><creatorcontrib>Jain, Rajan</creatorcontrib><creatorcontrib>LeBoeuf, Matthew R.</creatorcontrib><creatorcontrib>Wang, Qiaohong</creatorcontrib><creatorcontrib>Lu, Min Min</creatorcontrib><creatorcontrib>Epstein, Jonathan A.</creatorcontrib><title>Interconversion Between Intestinal Stem Cell Populations in Distinct Niches</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. 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| ispartof | Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6061), p.1420-1424 |
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| source | Alma/SFX Local Collection; Science Online科学在线 |
| subjects | Animals Biological and medical sciences Cell Cycle Cell Differentiation Cell Lineage Cell Proliferation Cells Cells, Cultured Crypts Cultured cells Descendants Endocrine cells Epithelial cells Epithelial Cells - cytology Fundamental and applied biological sciences. Psychology Homeodomain Proteins - analysis Homeodomain Proteins - genetics Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestine, Small - cytology Intestine, Small - drug effects Intestine. Mesentery Intestines Mice Models, Biological Multipotent Stem Cells - cytology Multipotent Stem Cells - physiology Neural stem cells Organoids Paneth Cells - cytology Stem Cell Niche Stem cells Tamoxifen - pharmacology Vertebrates: digestive system |
| title | Interconversion Between Intestinal Stem Cell Populations in Distinct Niches |
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