Impact of Preoperative Thrombocytosis on the Survival of Patients with Primary Colorectal Cancer

Background Although thrombocytosis has been reported in patients with various types of cancer, the association between thrombocytosis and the clinicopathological features of patients with colorectal cancer (CRC) has not been fully investigated. We evaluated the clinical features associated with thro...

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Bibliographic Details
Published in:World journal of surgery 2012-01, Vol.36 (1), p.192-200
Main Authors: Sasaki, Kazuhito, Kawai, Kazushige, Tsuno, Nelson H., Sunami, Eiji, Kitayama, Joji
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Cardiac Surgery
Clinicopathological Variable
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - complications
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Female
General Surgery
Humans
Logistic Models
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Platelet Count
Preoperative Period
Prognosis
Regional Lymph Node Metastasis
Retrospective Studies
Surgery
Survival Analysis
Survival Rate
Thoracic Surgery
Thrombocytosis
Thrombocytosis - blood
Thrombocytosis - diagnosis
Thrombocytosis - etiology
Treatment Outcome
Vascular Surgery
Venous Involvement
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Summary:Background Although thrombocytosis has been reported in patients with various types of cancer, the association between thrombocytosis and the clinicopathological features of patients with colorectal cancer (CRC) has not been fully investigated. We evaluated the clinical features associated with thrombocytosis in CRC. Materials and methods The medical records of 636 consecutive CRC patients undergoing surgery in our department between January 2002 and July 2008 were retrospectively reviewed. The correlation between the clinicopathological variables and the preoperative platelet count was analyzed by univariate and multivariate analyses. The impact of thrombocytosis on the prognosis of these patients was assessed, in comparison with the other clinicopathological variables. Results Platelet count showed significant correlation with gender, age, venous involvement, tumor size, depth of invasion, regional lymph node metastasis, distant metastasis in univariate analysis, and tumor size and depth of invasion were independent factors in multivariate analysis. The cancer-specific survival (CSS) of CRC patients with thrombocytosis was significantly shorter than that for those without thrombocytosis ( P  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-011-1329-7