Sulcus vocalis: evidence for autosomal dominant inheritance

We found evidence of autosomal dominant hereditary transmission of sulcus vocalis. Four dysphonic patients from three generations of the same family were submitted to videolaryngoscopic examination (three patients) and to direct laryngoscopy (one patient) to diagnose the hoarseness. Sulcus vocalis w...

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Bibliographic Details
Published in:Genetics and molecular research 2011-12, Vol.10 (4), p.3163-3168
Main Authors: Martins, R H G, Gonçalves, T M, Neves, D S, Fracalossi, T A, Tavares, E L M, Moretti-Ferreira, D
Format: Article
Language:English
Subjects:
Adult
Brazil
Child
Child, Preschool
Female
Genes, Dominant
Hoarseness - genetics
Hoarseness - physiopathology
Humans
Laryngoscopy
Male
Middle Aged
Pedigree
Phenotype
Vocal Cords - abnormalities
Vocal Cords - physiopathology
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Summary:We found evidence of autosomal dominant hereditary transmission of sulcus vocalis. Four dysphonic patients from three generations of the same family were submitted to videolaryngoscopic examination (three patients) and to direct laryngoscopy (one patient) to diagnose the hoarseness. Sulcus vocalis was diagnosed in all four patients. The finding of four affected individuals in three generations, with vertical transmission affecting man and women, is more consistent with autosomal dominant inheritance pattern; it is an etiological model that we propose for the sulcus vocalis in this pedigree.
ISSN:1676-5680
1676-5680
DOI:10.4238/2011.December.19.5