Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women

► Tumour necrosis factor alpha involved in the pathogenesis of metabolic syndrome. ► Impact of the G-308A TNF-α variant on components of the metabolic syndrome. ► TNF-α mutant allele associated with most of the metabolic risk factors. ► TNFα gene associated with components of metabolic syndrome. ► T...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2012-01, Vol.57 (1), p.32-36
Main Authors: Gupta, Vani, Gupta, Abhishek, Jafar, Tabrez, Gupta, Vandana, Agrawal, Suraksha, Srivastava, Nidhi, Kumar, Sandeep, Singh, Arun K., Natu, S.M., Agarwal, C.G., Agarwal, G.G.
Format: Article
Language:English
Subjects:
Adult
adults
alleles
Anthropometry
blood serum
Case-Control Studies
digestion
Female
females
Genetic Association Studies
Genetic Predisposition to Disease
HOMA index
homozygosity
Humans
hypercholesterolemia
hyperglycemia
hypertension
India
insulin resistance
Insulin Resistance - genetics
Leptin
Leptin - blood
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - genetics
mutants
obesity
Odds Ratio
pathogenesis
PCR
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
Risk Factors
TNF-alpha
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - genetics
tumor necrosis factors
women
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Summary:► Tumour necrosis factor alpha involved in the pathogenesis of metabolic syndrome. ► Impact of the G-308A TNF-α variant on components of the metabolic syndrome. ► TNF-α mutant allele associated with most of the metabolic risk factors. ► TNFα gene associated with components of metabolic syndrome. ► TNFα gene is not associated with Insulin resistance and hyperglycemia. Tumour necrosis factor alpha is a multifunctional proinflammatory cytokine involved in the pathogenesis of metabolic syndrome, insulin resistance, and obesity. Aim of this study is to investigate in a North Indian female population the impact of the G-308A TNF-α variant on various components of the metabolic syndrome, Insulin Resistance, serum TNF-α and Leptin levels. The G-308A TNF-α polymorphism has been studied in 269 females with metabolic syndrome (NCEP ATP III criteria) (age 31.91±6.05) and 272 healthy females without metabolic syndrome (age 30.96±7.01). The G-308A variant was detected by PCR amplification and Nco-1 digestion. Homozygous mutant genotype (AA) (p=
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2011.04.012