Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract

This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citiifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14...

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Published in:African journal of biotechnology 2011-10, Vol.10 (65), p.14566-14572
Main Authors: Serafini, M R, de Lima, CM, Santos, R C, Doria, GAA, de Jesus, JY, de Melo, MGD, dos Santos, JPA, Rabelo, T K, tes, V S, Fonseca, MJV, de Albuquerque, RLC, Quintans-Junior, L J, de Souza Araujo, AA
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Morinda citrifolia
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container_end_page 14572
container_issue 65
container_start_page 14566
container_title African journal of biotechnology
container_volume 10
creator Serafini, M R
de Lima, CM
Santos, R C
Doria, GAA
de Jesus, JY
de Melo, MGD
dos Santos, JPA
Rabelo, T K
tes, V S
Fonseca, MJV
de Albuquerque, RLC
Quintans-Junior, L J
de Souza Araujo, AA
description This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citiifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14 days. Biochemical and hematological parameters were determined after 14 days. Cytotoxic effects of the AEMC were determined by spectrophotometric 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay (at concentration of 0.05 to 25 mg/ml). The results showed that in the acute study in rats, the AEMC did not cause general behavior adverse effects and mortality. Also, AEMC did not show any cytotoxic effect at 0.05 to 12.5 mg/ml, only at 25 mg/ml. The AEMC does not appear to have significant toxicity.
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title Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract
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