Vitamin D Deficiency and Arterial Wall Stiffness in Children With Chronic Kidney Disease

Arterial wall stiffness is a recognized complication in children with chronic kidney disease (CKD). Vascular abnormalities in these patients are shown to predate cardiac abnormalities such as left ventricular hypertrophy and diastolic dysfunction. The etiology of vascular abnormalities in these pati...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric cardiology 2012, Vol.33 (1), p.122-128
Main Authors: Patange, Amit R., Valentini, Rudolph P., Du, Wei, Pettersen, Michael D.
Format: Article
Language:English
Subjects:
Adolescent
Alfacalcidol
Analysis
Biomarkers - blood
Calcifediol
Calcium - blood
Cardiac Surgery
Cardiology
Child
Children
Children's furniture
Chronic kidney failure
Female
Health aspects
Heart enlargement
Humans
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Original Article
Phosphorus - blood
Physiological aspects
Regression Analysis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Vascular Stiffness
Vascular Surgery
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamin D Deficiency - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Arterial wall stiffness is a recognized complication in children with chronic kidney disease (CKD). Vascular abnormalities in these patients are shown to predate cardiac abnormalities such as left ventricular hypertrophy and diastolic dysfunction. The etiology of vascular abnormalities in these patients currently is not clear. This study explored the relationship between various parameters of calcium–phosphorus metabolism including 25-hydroxy vitamin D and arterial wall stiffness in pediatric patients with CKD. This study investigated a cohort of 43 children with CKD who had no history of underlying congenital or structural cardiac disease. The Augmentation Index (AI), a measure of peripheral arterial reflective properties using radial artery tonometry, was used as an indirect measure of central aortic stiffness. Serum biochemical markers of calcium–phosphorus metabolism were simultaneously measured. Univariate testing showed that AI correlated with worsening kidney function. Serum 25-hydroxy vitamin D levels were low and correlated negatively with AI ( r  = −0.39; p  
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-011-0101-y