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Factors associated with diabetic nephropathy in subjects with proliferative retinopathy
Aim The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy. Methods We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with...
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| Published in: | International urology and nephrology 2012-02, Vol.44 (1), p.197-206 |
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| container_title | International urology and nephrology |
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| creator | Magri, Caroline Jane Calleja, Neville Buhagiar, Gerald Fava, Stephen Vassallo, Josanne |
| description | Aim
The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy.
Methods
We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with micro- (
n
= 66) or macroalbuminuria (
n
= 45). Both groups underwent 24-h blood pressure (BP) monitoring and were analysed regarding markers of the metabolic syndrome, inflammation (erythrocyte sedimentation rate [ESR] and high-sensitivity CRP [hsCRP]) and insulin resistance (HOMA-IR).
Results
Cases had significantly higher white cell count (
P
= 0.02), ESR (
P
|
| doi_str_mv | 10.1007/s11255-011-9958-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_915380385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2556625061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-216885af961f5ac513db79e7e153038cb993e0da18a09a0197ad4dd1a4ef4373</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMoun78AC9SvHiqzjTNNjmKuCoIXgSPIU2nbpbddk1SZf-9WeoHCJ7mMM_7zPAydopwiQDVVUAshMgBMVdKyBx32ARFxfNCyHKXTYAD5jgt-AE7DGEBAEoC7LODAgVOy0pM2MvM2Nj7kJkQeutMpCb7cHGeNc7UFJ3NOlrPfb82cb7JXJeFoV6QjWGk1r5fupa8ie6dMp8C3Yges73WLAOdfM0j9jy7fb65zx-f7h5urh9zyyuIeYFTKYVp1RRbYaxA3tSVoopQcODS1kpxgsagNKAMoKpMUzYNmpLaklf8iF2M2vTI20Ah6pULlpZL01E_BK2SRyaRSOT5H3LRD75LvyWolCCkLBOEI2R9H4KnVq-9Wxm_0Qh6W7keK9epcr2tXGPKnH2Jh3pFzU_iu-MEFCMQ0qp7Jf97-X_rJyzFjLI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>914805884</pqid></control><display><type>article</type><title>Factors associated with diabetic nephropathy in subjects with proliferative retinopathy</title><source>Springer Nature</source><creator>Magri, Caroline Jane ; Calleja, Neville ; Buhagiar, Gerald ; Fava, Stephen ; Vassallo, Josanne</creator><creatorcontrib>Magri, Caroline Jane ; Calleja, Neville ; Buhagiar, Gerald ; Fava, Stephen ; Vassallo, Josanne</creatorcontrib><description><![CDATA[Aim
The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy.
Methods
We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with micro- (
n
= 66) or macroalbuminuria (
n
= 45). Both groups underwent 24-h blood pressure (BP) monitoring and were analysed regarding markers of the metabolic syndrome, inflammation (erythrocyte sedimentation rate [ESR] and high-sensitivity CRP [hsCRP]) and insulin resistance (HOMA-IR).
Results
Cases had significantly higher white cell count (
P
= 0.02), ESR (
P
< 0.001), platelets (
P
= 0.02), triglycerides (
P
= 0.001), uric acid (
P
< 0.001), daytime and night-time systolic BP (
P
= 0.001 &
P
= 0.001, respectively), diastolic BP (
P
= 0.007 &
P
= 0.001), pulse pressure (
P
= 0.02 & 0.055) and mean arterial pressure (
P
= 0.001 &
P
< 0.001) in univariate analysis. Cases had a lower haemoglobin level (
P
= 0.01) and estimated glomerular filtration rate (eGFR) (
P
= 0.002) in comparison with controls. Multivariate analysis showed that night-time diastolic BP (
P
= 0.002,
B
= 1.057), platelet count (
P
= 0.018,
B
= 1.007) and eGFR (
P
< 0.001,
B
= 0.097) are independent predictors of diabetic nephropathy. Platelet count (
P
= 0.045,
B
= 1.006), night-time mean diastolic BP (
P
= 0.029,
B
= 1.042) and eGFR (
P
= 0.001,
B
= 0.975) were also found to be independent predictors of the occurrence of microalbuminuria.
Conclusions
By analysing factors associated with diabetic nephropathy rather than microvascular disease in general, this study provides evidence that night-time diastolic BP and a relative increase in platelet count are associated with incipient diabetic nephropathy.]]></description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-011-9958-1</identifier><identifier>PMID: 21516475</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Albuminuria - etiology ; Blood Pressure ; Blood Sedimentation ; C-Reactive Protein - metabolism ; Circadian Rhythm ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - complications ; Diabetic Nephropathies - physiopathology ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - physiopathology ; Diastole ; Female ; Glomerular Filtration Rate ; Hemoglobins - metabolism ; Humans ; Insulin Resistance ; Leukocyte Count ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Nephrology ; Nephrology – Original Paper ; Phenotype ; Platelet Count ; Pulse ; Systole ; Triglycerides - blood ; Uric Acid - blood ; Urology</subject><ispartof>International urology and nephrology, 2012-02, Vol.44 (1), p.197-206</ispartof><rights>Springer Science+Business Media, B.V. 2011</rights><rights>Springer Science+Business Media, B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-216885af961f5ac513db79e7e153038cb993e0da18a09a0197ad4dd1a4ef4373</citedby><cites>FETCH-LOGICAL-c370t-216885af961f5ac513db79e7e153038cb993e0da18a09a0197ad4dd1a4ef4373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21516475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magri, Caroline Jane</creatorcontrib><creatorcontrib>Calleja, Neville</creatorcontrib><creatorcontrib>Buhagiar, Gerald</creatorcontrib><creatorcontrib>Fava, Stephen</creatorcontrib><creatorcontrib>Vassallo, Josanne</creatorcontrib><title>Factors associated with diabetic nephropathy in subjects with proliferative retinopathy</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description><![CDATA[Aim
The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy.
Methods
We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with micro- (
n
= 66) or macroalbuminuria (
n
= 45). Both groups underwent 24-h blood pressure (BP) monitoring and were analysed regarding markers of the metabolic syndrome, inflammation (erythrocyte sedimentation rate [ESR] and high-sensitivity CRP [hsCRP]) and insulin resistance (HOMA-IR).
Results
Cases had significantly higher white cell count (
P
= 0.02), ESR (
P
< 0.001), platelets (
P
= 0.02), triglycerides (
P
= 0.001), uric acid (
P
< 0.001), daytime and night-time systolic BP (
P
= 0.001 &
P
= 0.001, respectively), diastolic BP (
P
= 0.007 &
P
= 0.001), pulse pressure (
P
= 0.02 & 0.055) and mean arterial pressure (
P
= 0.001 &
P
< 0.001) in univariate analysis. Cases had a lower haemoglobin level (
P
= 0.01) and estimated glomerular filtration rate (eGFR) (
P
= 0.002) in comparison with controls. Multivariate analysis showed that night-time diastolic BP (
P
= 0.002,
B
= 1.057), platelet count (
P
= 0.018,
B
= 1.007) and eGFR (
P
< 0.001,
B
= 0.097) are independent predictors of diabetic nephropathy. Platelet count (
P
= 0.045,
B
= 1.006), night-time mean diastolic BP (
P
= 0.029,
B
= 1.042) and eGFR (
P
= 0.001,
B
= 0.975) were also found to be independent predictors of the occurrence of microalbuminuria.
Conclusions
By analysing factors associated with diabetic nephropathy rather than microvascular disease in general, this study provides evidence that night-time diastolic BP and a relative increase in platelet count are associated with incipient diabetic nephropathy.]]></description><subject>Aged</subject><subject>Albuminuria - etiology</subject><subject>Blood Pressure</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - metabolism</subject><subject>Circadian Rhythm</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - physiopathology</subject><subject>Diastole</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nephrology</subject><subject>Nephrology – Original Paper</subject><subject>Phenotype</subject><subject>Platelet Count</subject><subject>Pulse</subject><subject>Systole</subject><subject>Triglycerides - blood</subject><subject>Uric Acid - blood</subject><subject>Urology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMoun78AC9SvHiqzjTNNjmKuCoIXgSPIU2nbpbddk1SZf-9WeoHCJ7mMM_7zPAydopwiQDVVUAshMgBMVdKyBx32ARFxfNCyHKXTYAD5jgt-AE7DGEBAEoC7LODAgVOy0pM2MvM2Nj7kJkQeutMpCb7cHGeNc7UFJ3NOlrPfb82cb7JXJeFoV6QjWGk1r5fupa8ie6dMp8C3Yges73WLAOdfM0j9jy7fb65zx-f7h5urh9zyyuIeYFTKYVp1RRbYaxA3tSVoopQcODS1kpxgsagNKAMoKpMUzYNmpLaklf8iF2M2vTI20Ah6pULlpZL01E_BK2SRyaRSOT5H3LRD75LvyWolCCkLBOEI2R9H4KnVq-9Wxm_0Qh6W7keK9epcr2tXGPKnH2Jh3pFzU_iu-MEFCMQ0qp7Jf97-X_rJyzFjLI</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Magri, Caroline Jane</creator><creator>Calleja, Neville</creator><creator>Buhagiar, Gerald</creator><creator>Fava, Stephen</creator><creator>Vassallo, Josanne</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Factors associated with diabetic nephropathy in subjects with proliferative retinopathy</title><author>Magri, Caroline Jane ; Calleja, Neville ; Buhagiar, Gerald ; Fava, Stephen ; Vassallo, Josanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-216885af961f5ac513db79e7e153038cb993e0da18a09a0197ad4dd1a4ef4373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Albuminuria - etiology</topic><topic>Blood Pressure</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - metabolism</topic><topic>Circadian Rhythm</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - physiopathology</topic><topic>Diastole</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nephrology</topic><topic>Nephrology – Original Paper</topic><topic>Phenotype</topic><topic>Platelet Count</topic><topic>Pulse</topic><topic>Systole</topic><topic>Triglycerides - blood</topic><topic>Uric Acid - blood</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magri, Caroline Jane</creatorcontrib><creatorcontrib>Calleja, Neville</creatorcontrib><creatorcontrib>Buhagiar, Gerald</creatorcontrib><creatorcontrib>Fava, Stephen</creatorcontrib><creatorcontrib>Vassallo, Josanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magri, Caroline Jane</au><au>Calleja, Neville</au><au>Buhagiar, Gerald</au><au>Fava, Stephen</au><au>Vassallo, Josanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with diabetic nephropathy in subjects with proliferative retinopathy</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>44</volume><issue>1</issue><spage>197</spage><epage>206</epage><pages>197-206</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract><![CDATA[Aim
The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy.
Methods
We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with micro- (
n
= 66) or macroalbuminuria (
n
= 45). Both groups underwent 24-h blood pressure (BP) monitoring and were analysed regarding markers of the metabolic syndrome, inflammation (erythrocyte sedimentation rate [ESR] and high-sensitivity CRP [hsCRP]) and insulin resistance (HOMA-IR).
Results
Cases had significantly higher white cell count (
P
= 0.02), ESR (
P
< 0.001), platelets (
P
= 0.02), triglycerides (
P
= 0.001), uric acid (
P
< 0.001), daytime and night-time systolic BP (
P
= 0.001 &
P
= 0.001, respectively), diastolic BP (
P
= 0.007 &
P
= 0.001), pulse pressure (
P
= 0.02 & 0.055) and mean arterial pressure (
P
= 0.001 &
P
< 0.001) in univariate analysis. Cases had a lower haemoglobin level (
P
= 0.01) and estimated glomerular filtration rate (eGFR) (
P
= 0.002) in comparison with controls. Multivariate analysis showed that night-time diastolic BP (
P
= 0.002,
B
= 1.057), platelet count (
P
= 0.018,
B
= 1.007) and eGFR (
P
< 0.001,
B
= 0.097) are independent predictors of diabetic nephropathy. Platelet count (
P
= 0.045,
B
= 1.006), night-time mean diastolic BP (
P
= 0.029,
B
= 1.042) and eGFR (
P
= 0.001,
B
= 0.975) were also found to be independent predictors of the occurrence of microalbuminuria.
Conclusions
By analysing factors associated with diabetic nephropathy rather than microvascular disease in general, this study provides evidence that night-time diastolic BP and a relative increase in platelet count are associated with incipient diabetic nephropathy.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21516475</pmid><doi>10.1007/s11255-011-9958-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-1623 |
| ispartof | International urology and nephrology, 2012-02, Vol.44 (1), p.197-206 |
| issn | 0301-1623 1573-2584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_915380385 |
| source | Springer Nature |
| subjects | Aged Albuminuria - etiology Blood Pressure Blood Sedimentation C-Reactive Protein - metabolism Circadian Rhythm Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetic Nephropathies - blood Diabetic Nephropathies - complications Diabetic Nephropathies - physiopathology Diabetic Retinopathy - blood Diabetic Retinopathy - complications Diabetic Retinopathy - physiopathology Diastole Female Glomerular Filtration Rate Hemoglobins - metabolism Humans Insulin Resistance Leukocyte Count Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Nephrology Nephrology – Original Paper Phenotype Platelet Count Pulse Systole Triglycerides - blood Uric Acid - blood Urology |
| title | Factors associated with diabetic nephropathy in subjects with proliferative retinopathy |
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