Prevalence of Endocrine Disorders in Morbidly Obese Patients and the Effects of Bariatric Surgery on Endocrine and Metabolic Parameters

Background Several endocrine abnormalities, including hypothyroidism and Cushing’s syndrome (CS), are considered as causative factors of obesity. The aim of this study was to evaluate the prevalence of endocrine disorders and obesity-associated co-morbidities, as well as the impact of substantial we...

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Bibliographic Details
Published in:Obesity surgery 2012-01, Vol.22 (1), p.62-69
Main Authors: Janković, Draženka, Wolf, Peter, Anderwald, Christian-Heinz, Winhofer, Yvonne, Promintzer-Schifferl, Miriam, Hofer, Astrid, Langer, Felix, Prager, Gerhard, Ludvik, Bernhard, Gessl, Alois, Luger, Anton, Krebs, Michael
Format: Article
Language:English
Subjects:
Adult
Austria - epidemiology
Bariatric Surgery - statistics & numerical data
Biomarkers - blood
Case-Control Studies
Clinical Research
Cushing Syndrome - complications
Cushing Syndrome - epidemiology
Cushing Syndrome - metabolism
Cushing Syndrome - surgery
Effects
Endocrine system
Female
Follow-Up Studies
Gastrointestinal surgery
Glucose Tolerance Test
Humans
Hypothyroidism - complications
Hypothyroidism - epidemiology
Hypothyroidism - metabolism
Hypothyroidism - surgery
Insulin Resistance
Male
Medical disorders
Medicine
Medicine & Public Health
Obesity
Obesity, Morbid - epidemiology
Obesity, Morbid - etiology
Obesity, Morbid - metabolism
Obesity, Morbid - surgery
Prevalence
Retrospective Studies
Surgery
Thyrotropin - blood
Weight Loss
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Summary:Background Several endocrine abnormalities, including hypothyroidism and Cushing’s syndrome (CS), are considered as causative factors of obesity. The aim of this study was to evaluate the prevalence of endocrine disorders and obesity-associated co-morbidities, as well as the impact of substantial weight loss. Methods Screening was performed in 433 consecutive morbidly obese patients (age 41 ± 12 years; BMI 47 ± 6.9 kg/m 2 ; women 76%). A 1-mg dexamethasone suppression test (1-mg DST) was conducted to exclude CS, and thyrotropin (TSH) was measured to exclude hypothyroidism. Insulin sensitivity was estimated from oral glucose tolerance tests employing the Clamp-like index. Examinations were carried out at baseline, as well as at 6 and 12 months postoperatively. Results The prevalence of CS was below 0.6%. Before surgery, TSH was elevated compared to an age- and sex-matched normal weight control group (2.4 ± 1.2 vs. 1.5 ± 0.7 μU/ml; p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-011-0545-4