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SUMO playing tag with ubiquitin

In addition to being structurally related, the protein modifiers ubiquitin and SUMO (small ubiquitin-related modifier), share a multitude of functional interrelations. These include the targeting of the same attachment sites in certain substrates, and SUMO-dependent ubiquitylation in others. Notably...

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Published in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2012, Vol.37 (1), p.23-31
Main Authors:	Praefcke, Gerrit J.K., Hofmann, Kay, Dohmen, R. Jürgen
Format:	Article
Language:	English
Subjects:	Animals cell growth DNA Damage enzymes Enzymes - metabolism equipment maintenance and repair genome Humans pathogens SUMO-1 Protein - metabolism ubiquitin Ubiquitins - metabolism
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description	In addition to being structurally related, the protein modifiers ubiquitin and SUMO (small ubiquitin-related modifier), share a multitude of functional interrelations. These include the targeting of the same attachment sites in certain substrates, and SUMO-dependent ubiquitylation in others. Notably, several cellular processes, including the targeting of repair machinery to DNA damage sites, require the sequential sumoylation and ubiquitylation of distinct substrates. Some proteins promote both modifications. By contrast, the activity of some enzymes that control either sumoylation or ubiquitylation is regulated by the respective other modification. In this review, we summarize recent findings regarding intersections between SUMO and ubiquitin that influence genome stability and cell growth and which are relevant in pathogen resistance and cancer treatment.
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subjects	Animals cell growth DNA Damage enzymes Enzymes - metabolism equipment maintenance and repair genome Humans pathogens SUMO-1 Protein - metabolism ubiquitin Ubiquitins - metabolism
title	SUMO playing tag with ubiquitin
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