Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

The biological processes controlling human growth are diverse, complex and poorly understood. Genetic factors are important and human height has been shown to be a highly polygenic trait to which common and rare genetic variation contributes. Weaver syndrome is a human overgrowth condition character...

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Bibliographic Details
Published in:	Oncotarget 2011-12, Vol.2 (12), p.1127-1133
Main Authors:	Tatton-Brown, Katrina, Hanks, Sandra, Ruark, Elise, Zachariou, Anna, Duarte, Silvana Del Vecchio, Ramsay, Emma, Snape, Katie, Murray, Anne, Perdeaux, Elizabeth R, Seal, Sheila, Loveday, Chey, Banka, Siddharth, Clericuzio, Carol, Flinter, Frances, Magee, Alex, McConnell, Vivienne, Patton, Michael, Raith, Wolfgang, Rankin, Julia, Splitt, Miranda, Strenger, Volker, Taylor, Clare, Wheeler, Patricia, Temple, I Karen, Cole, Trevor, Douglas, Jenny, Rahman, Nazneen
Format:	Article
Language:	English
Subjects:	Abnormalities, Multiple - genetics Amino Acid Sequence Body Height Congenital Hypothyroidism - genetics Craniofacial Abnormalities - genetics DNA-Binding Proteins - genetics Enhancer of Zeste Homolog 2 Protein Facies Female Germ-Line Mutation Growth Disorders - genetics Hand Deformities, Congenital - genetics Histone Methyltransferases Histone-Lysine N-Methyltransferase - genetics Histones - genetics Humans Male Polycomb Repressive Complex 2 Research Papers Sequence Analysis, DNA Transcription Factors - genetics
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