Yeast as a model to study mitochondrial mechanisms in ageing

Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respira...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2010-07, Vol.131 (7), p.494-502
Main Authors: Barros, Mario H., da Cunha, Fernanda M., Oliveira, Graciele A., Tahara, Erich B., Kowaltowski, Alicia J.
Format: Article
Language:English
Subjects:
Age Factors
Aging - metabolism
Aging - pathology
Autophagy
Caloric Restriction
Calorie restriction
Cell Nucleus - metabolism
Cell Respiration
DNA, Fungal - metabolism
DNA, Mitochondrial - metabolism
Energy Metabolism
Humans
Mitochondria - metabolism
Mitochondria - pathology
NAD
Oxidative Stress
Reactive Oxygen Species
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - metabolism
Signal Transduction
SIR
TOR
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Summary:Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria–nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2010.04.008