APOE and cholesterol homeostasis in Alzheimer's disease

Converging evidence from clinical and pathological studies indicate the presence of important relationships between the ongoing deterioration of brain lipid homeostasis, vascular changes and the pathophysiology of sporadic Alzheimer's disease (AD). These associations include the recognition of...

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Bibliographic Details
Published in:Trends in molecular medicine 2010-10, Vol.16 (10), p.469-477
Main Authors: Leduc, Valérie, Jasmin-Bélanger, Stéphanie, Poirier, Judes
Format: Article
Language:English
Subjects:
Alzheimer Disease - complications
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Amyloid beta-Peptides - metabolism
Animals
Apolipoproteins E - metabolism
Cardiovascular Diseases - complications
Cholesterol - metabolism
Homeostasis
Humans
Pathology
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Summary:Converging evidence from clinical and pathological studies indicate the presence of important relationships between the ongoing deterioration of brain lipid homeostasis, vascular changes and the pathophysiology of sporadic Alzheimer's disease (AD). These associations include the recognition of cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ as major genetic risk factors for common AD and observations associating risk factors for cardiovascular disease such as high midlife plasma cholesterol, diabetes, stroke, obesity and hypertension to dementia. Moreover, recent clinical findings lend support to the notion that progressive deterioration of cholesterol homeostasis in AD is a central player in the disease pathophysiology and is, therefore, a potential therapeutic target for disease prevention.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2010.07.008