Why We Don't Need a Relative Risk Standard for Adolescent HIV Vaccine Trials in South Africa

Snyder and colleagues underscore the need to enroll adolescents in HIV prevention trials in order to realize much-needed interventions for this deserving group. Current ethical guidelines governing child trials generally assert that procedures that do not hold out the prospect of direct benefit shou...

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Bibliographic Details
Published in:American journal of bioethics 2011-06, Vol.11 (6), p.21-22
Main Author: Slack, Catherine M.
Format: Article
Language:English
Subjects:
Adolescent
Adults
AIDS Vaccines - administration & dosage
AIDS Vaccines - adverse effects
AIDS Vaccines - immunology
Benefits
Bioethics
Clinical trials
Clinical Trials as Topic - ethics
Clinical Trials as Topic - methods
Community-Based Participatory Research - ethics
Community-Based Participatory Research - methods
HIV Infections - immunology
HIV Infections - prevention & control
Human immunodeficiency virus
Humans
Medical research
Nontherapeutic Human Experimentation - ethics
Patient Selection - ethics
Primary Prevention - ethics
Primary Prevention - methods
Risk
Risk-Taking
South Africa
Vaccination and vaccines
Youth
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Summary:Snyder and colleagues underscore the need to enroll adolescents in HIV prevention trials in order to realize much-needed interventions for this deserving group. Current ethical guidelines governing child trials generally assert that procedures that do not hold out the prospect of direct benefit should approximate minimal risk, or a minor increase over that. Adolescent HIV vaccine trials could conceivably fit these requirements. This author argues that adolescent enrollment needs to wait for reasonable amounts of adult data about the potential benefit of the experimental HIV vaccine. Adapted from the source document.
ISSN:1526-5161
1536-0075
DOI:10.1080/15265161.2011.566671