An open-label, randomized, multi-center study of the immunogenicity and safety of DTaP–IPV ( Kinrix ™) co-administered with MMR vaccine with or without varicella vaccine in healthy pre-school age children

• Published in: Vaccine 2012-01, Vol.30 (3), p.668-674
• Main Authors: Klein, Nicola P, Weston, Wayde M, Kuriyakose, Sherine, Kolhe, Devayani, Howe, Barbara, Friedland, Leonard R, Van Der Meeren, Olivier
• Format: Article
• Language: English
• Subjects: Age; Allergy and Immunology; Antibodies, Bacterial - blood; Antibodies, Viral - blood; antigens; Booster; Chickenpox Vaccine - administration & dosage; Chickenpox Vaccine - adverse effects; Chickenpox Vaccine - immunology; Child; Child, Preschool; children; Clinical trials; Confidence intervals; Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage; Diphtheria-Tetanus-acellular Pertussis Vaccines - adverse effects; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology; Drug-Related Side Effects and Adverse Reactions - epidemiology; DTaP–IPV vaccine; Enterovirus C; Female; Humans; immune response; Immunization; Immunogenicity; influenza; Male; Measles-Mumps-Rubella Vaccine - administration & dosage; Measles-Mumps-Rubella Vaccine - adverse effects; Measles-Mumps-Rubella Vaccine - immunology; Measles–mumps–rubella vaccine; Mumps; Pertussis; Poliomyelitis; Poliovirus; Poliovirus Vaccine, Inactivated - administration & dosage; Poliovirus Vaccine, Inactivated - adverse effects; Poliovirus Vaccine, Inactivated - immunology; Tetanus; vaccination; Vaccination - methods; Vaccines; Varicella vaccine
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.10.065

Highlights ► This study evaluated co-administration of DTaP–IPV and MMR with varicella vaccine in 4–6 year olds. ► Varicella vaccine with DTaP–IPV and MMR did not impact immunogenicity of DTaP–IPV. ► Co-administration of varicella vaccine with DTaP–IPV and MMR was well tolerated. ► Results support co-administration of DTaP–IPV, MMR, and varicella vaccines in 4–6-year-olds.