Rotavirus Cerebellitis: New Aspects to an Old Foe?

Abstract Rotavirus infection is a significant cause of childhood morbidity and mortality worldwide. Although infection primarily causes gastroenteritis and dehydration, systemic signs and neurologic manifestations in rotavirus infection are widely recognized. The pathophysiologic origins of neurolog...

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Bibliographic Details
Published in:Pediatric neurology 2012, Vol.46 (1), p.48-50
Main Authors: Thompson, Melanie J., MB BS, Gowdie, Peter J., MB BS, Kirkwood, Carl D., PhD, Doherty, Richard R., MB BS, Fahey, Michael, PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cerebellar Diseases - etiology
Cerebellar Diseases - virology
Child, Preschool
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Medical sciences
Nervous system
Neurology
Pediatrics
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rotavirus
Rotavirus - genetics
Rotavirus Infections - complications
Rotavirus Infections - pathology
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Summary:Abstract Rotavirus infection is a significant cause of childhood morbidity and mortality worldwide. Although infection primarily causes gastroenteritis and dehydration, systemic signs and neurologic manifestations in rotavirus infection are widely recognized. The pathophysiologic origins of neurologic signs in rotavirus infection remain incompletely understood. We present a 4-year-old girl with clinical features of severe cerebellitis in association with abnormalities detected on magnetic resonance imaging. Rotavirus nucleic acid was demonstrated in both serum and cerebrospinal fluid. Severe neurologic sequelae remain after 2 years of follow-up. This report adds further evidence supporting a direct role for rotavirus in neurologic illness.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2011.10.002