Ultra-sensitive suspended graphene nanocomposite cancer sensors with strong suppression of electrical noise

► Cancer sensor based on suspended layer-by-layer self-assembled graphene beams. ► Cancer sensor exhibiting an ultra high sensitivity due to graphene material properties in nature. ► Noise spectra analysis confirming the lower level of 1/f noise in suspended graphene devices. The cancer sensor based...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2012-01, Vol.31 (1), p.105-109
Main Authors: Zhang, Bo, Li, Qiao, Cui, Tianhong
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Biosensing Techniques - instrumentation
Biotechnology
Cancer sensor
Electrical noise
Equipment Design
Equipment Failure Analysis
Fundamental and applied biological sciences. Psychology
Graphene
Graphite - chemistry
Humans
Male
Nanostructures - chemistry
Prostate-Specific Antigen - analysis
Prostatic Neoplasms - diagnosis
Self-assembly
Sensitivity and Specificity
Signal-To-Noise Ratio
Suspended beam
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Summary:► Cancer sensor based on suspended layer-by-layer self-assembled graphene beams. ► Cancer sensor exhibiting an ultra high sensitivity due to graphene material properties in nature. ► Noise spectra analysis confirming the lower level of 1/f noise in suspended graphene devices. The cancer sensor based on suspended layer-by-layer self-assembled graphene reported in the paper exhibits an ultra high sensitivity due to graphene material properties in nature. By simply immersing the substrate alternatively into charged graphene suspensions and polyions, graphene nanoplatelets are self-assembled in the channel as the sensing region, followed by SF6 dry etching to suspend the structure. Conductance shift curves demonstrate that the suspended graphene sensors functionalized with specific anti-PSA antibodies as bioreceptor are capable of detecting prostate specific antigen down to 0.4fg/ml (11aM), at least one order of magnitude lower than unsuspended devices. The noise spectra analysis confirms the lower level of 1/f noise in suspended graphene devices. Carbon nanotube sensor under the same conditions of design, manufacture, and measurement are implemented to compare with graphene devices, showing the prominent advantages of graphene as a sensing material.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2011.09.046