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Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation
Background It is commonly recommended that patients refrain from driving for 24 hours after endoscopy for which sedation is given. Objective The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driv...
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| Published in: | Gastrointestinal endoscopy 2012-03, Vol.75 (3), p.506-512 |
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| cites | cdi_FETCH-LOGICAL-c503t-38bd1bb4b12f7e6124d776f7fe344a7d166c2b364762ea88091c2615fcd81b833 |
| container_end_page | 512 |
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| container_title | Gastrointestinal endoscopy |
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| creator | Horiuchi, Akira, MD Nakayama, Yoshiko, MD Fujii, Hideyasu Katsuyama, Yoshihiko, PhD Ohmori, Shigeru, PhD Tanaka, Naoki, MD |
| description | Background It is commonly recommended that patients refrain from driving for 24 hours after endoscopy for which sedation is given. Objective The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driving might be safe. Design A prospective, consecutive study. Setting Municipal hospital outpatients. Patients This study involved 48 consecutive patients scheduled for colonoscopy with propofol sedation. Intervention Patient clinical features, psychomotor recovery, and blood concentrations of propofol were assessed. Psychomotor recovery was assessed before colonoscopy and 1 and 2 hours after colonoscopy by using the number connection test and a driving simulator test. Main Outcome Measurements Clinical features, psychomotor recovery, and blood concentration of propofol. Results All patients successfully completed the post-sedation assessments. Although there was a significant difference in results of the number connection test between before colonoscopy and 1 hour after colonoscopy, all number connection test results were within normal limits ( |
| doi_str_mv | 10.1016/j.gie.2011.08.020 |
| format | article |
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Objective The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driving might be safe. Design A prospective, consecutive study. Setting Municipal hospital outpatients. Patients This study involved 48 consecutive patients scheduled for colonoscopy with propofol sedation. Intervention Patient clinical features, psychomotor recovery, and blood concentrations of propofol were assessed. Psychomotor recovery was assessed before colonoscopy and 1 and 2 hours after colonoscopy by using the number connection test and a driving simulator test. Main Outcome Measurements Clinical features, psychomotor recovery, and blood concentration of propofol. Results All patients successfully completed the post-sedation assessments. Although there was a significant difference in results of the number connection test between before colonoscopy and 1 hour after colonoscopy, all number connection test results were within normal limits (<40 seconds). Scores were as follows: mean time (standard deviation) before colonoscopy, 32.2 (2.0) seconds (range 29-36 seconds) versus after colonoscopy, 32.7 (2.0) seconds (range 27-38 seconds); P = .0019. Driving skills had recovered to the baseline levels 1 hour after colonoscopy. Scores were as follows: tracking error (%) before colonoscopy, 45.0 (5.6) versus after colonoscopy, 46.0 (5.5); P = .61; accelerating reaction time in seconds before colonoscopy, 0.65 (0.15) versus after colonoscopy, 0.62 (0.14); P = .40; braking reaction time in seconds before colonoscopy, 0.58 (0.13) versus after colonoscopy, 0.61 (0.13); P = .50. Limitations Small sample size, single-center study. Conclusion Although consistent findings on the number connection test and driving simulation (psychomotor recovery) test are present as early as 1 hour after propofol sedation, a study of additional numbers of patients as well as different patient populations are needed before these results can be universally recommended.</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/j.gie.2011.08.020</identifier><identifier>PMID: 22115604</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>Maryland heights, MO: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Colonoscopy ; Conscious Sedation ; Digestive system. Abdomen ; Endoscopy ; Female ; Gastroenterology and Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Humans ; Hypnotics and Sedatives - blood ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Propofol - blood ; Prospective Studies ; Psychomotor Performance ; Recovery of Function</subject><ispartof>Gastrointestinal endoscopy, 2012-03, Vol.75 (3), p.506-512</ispartof><rights>American Society for Gastrointestinal Endoscopy</rights><rights>2012 American Society for Gastrointestinal Endoscopy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-38bd1bb4b12f7e6124d776f7fe344a7d166c2b364762ea88091c2615fcd81b833</citedby><cites>FETCH-LOGICAL-c503t-38bd1bb4b12f7e6124d776f7fe344a7d166c2b364762ea88091c2615fcd81b833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25600325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22115604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horiuchi, Akira, MD</creatorcontrib><creatorcontrib>Nakayama, Yoshiko, MD</creatorcontrib><creatorcontrib>Fujii, Hideyasu</creatorcontrib><creatorcontrib>Katsuyama, Yoshihiko, PhD</creatorcontrib><creatorcontrib>Ohmori, Shigeru, PhD</creatorcontrib><creatorcontrib>Tanaka, Naoki, MD</creatorcontrib><title>Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background It is commonly recommended that patients refrain from driving for 24 hours after endoscopy for which sedation is given. Objective The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driving might be safe. Design A prospective, consecutive study. Setting Municipal hospital outpatients. Patients This study involved 48 consecutive patients scheduled for colonoscopy with propofol sedation. Intervention Patient clinical features, psychomotor recovery, and blood concentrations of propofol were assessed. Psychomotor recovery was assessed before colonoscopy and 1 and 2 hours after colonoscopy by using the number connection test and a driving simulator test. Main Outcome Measurements Clinical features, psychomotor recovery, and blood concentration of propofol. Results All patients successfully completed the post-sedation assessments. Although there was a significant difference in results of the number connection test between before colonoscopy and 1 hour after colonoscopy, all number connection test results were within normal limits (<40 seconds). Scores were as follows: mean time (standard deviation) before colonoscopy, 32.2 (2.0) seconds (range 29-36 seconds) versus after colonoscopy, 32.7 (2.0) seconds (range 27-38 seconds); P = .0019. Driving skills had recovered to the baseline levels 1 hour after colonoscopy. Scores were as follows: tracking error (%) before colonoscopy, 45.0 (5.6) versus after colonoscopy, 46.0 (5.5); P = .61; accelerating reaction time in seconds before colonoscopy, 0.65 (0.15) versus after colonoscopy, 0.62 (0.14); P = .40; braking reaction time in seconds before colonoscopy, 0.58 (0.13) versus after colonoscopy, 0.61 (0.13); P = .50. Limitations Small sample size, single-center study. Conclusion Although consistent findings on the number connection test and driving simulation (psychomotor recovery) test are present as early as 1 hour after propofol sedation, a study of additional numbers of patients as well as different patient populations are needed before these results can be universally recommended.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Colonoscopy</subject><subject>Conscious Sedation</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - blood</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Propofol - blood</subject><subject>Prospective Studies</subject><subject>Psychomotor Performance</subject><subject>Recovery of Function</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kVGL1DAQx4Mo3t7pB_BF-iI-tc6k3aRFEOTwVDhQUEGfQppM77J2k72kXem3N8uuHvggDMzL7z8z_IaxZwgVAopXm-rGUcUBsYK2Ag4P2Aqhk6WQsnvIVpChco0gz9h5ShsAaHmNj9kZ54hrAc2K_ficFnMbtmEKsYhkwp7iUmhvi34MwRa7GHZhCGMx0p7GwvnChDH4kEzYLcWvW_LFnJy_uQcTWT254J-wR4MeEz099Qv27erd18sP5fWn9x8v316XZg31VNZtb7Hvmx75IEkgb6yUYpAD1U2jpUUhDO9r0UjBSbctdGi4wPVgbIt9W9cX7OVxbr7gbqY0qa1LhsZRewpzUh3nTdc1DWQSj6SJIaVIg9pFt9VxUQjqIFRtVBaqDkIVtCoLzZnnp-lzvyX7N_HHYAZenACdjB6HqL1x6Z7LENR8nbnXR46yi72jqJJx5A1Zl7VPygb33zPe_JM2o_MuL_xJC6VNmKPPkhWqxBWoL4fPHx6PCDzX9_o3I-2ocw</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Horiuchi, Akira, MD</creator><creator>Nakayama, Yoshiko, MD</creator><creator>Fujii, Hideyasu</creator><creator>Katsuyama, Yoshihiko, PhD</creator><creator>Ohmori, Shigeru, PhD</creator><creator>Tanaka, Naoki, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation</title><author>Horiuchi, Akira, MD ; Nakayama, Yoshiko, MD ; Fujii, Hideyasu ; Katsuyama, Yoshihiko, PhD ; Ohmori, Shigeru, PhD ; Tanaka, Naoki, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-38bd1bb4b12f7e6124d776f7fe344a7d166c2b364762ea88091c2615fcd81b833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Colonoscopy</topic><topic>Conscious Sedation</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - blood</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Propofol - blood</topic><topic>Prospective Studies</topic><topic>Psychomotor Performance</topic><topic>Recovery of Function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horiuchi, Akira, MD</creatorcontrib><creatorcontrib>Nakayama, Yoshiko, MD</creatorcontrib><creatorcontrib>Fujii, Hideyasu</creatorcontrib><creatorcontrib>Katsuyama, Yoshihiko, PhD</creatorcontrib><creatorcontrib>Ohmori, Shigeru, PhD</creatorcontrib><creatorcontrib>Tanaka, Naoki, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horiuchi, Akira, MD</au><au>Nakayama, Yoshiko, MD</au><au>Fujii, Hideyasu</au><au>Katsuyama, Yoshihiko, PhD</au><au>Ohmori, Shigeru, PhD</au><au>Tanaka, Naoki, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>75</volume><issue>3</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background It is commonly recommended that patients refrain from driving for 24 hours after endoscopy for which sedation is given. Objective The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driving might be safe. Design A prospective, consecutive study. Setting Municipal hospital outpatients. Patients This study involved 48 consecutive patients scheduled for colonoscopy with propofol sedation. Intervention Patient clinical features, psychomotor recovery, and blood concentrations of propofol were assessed. Psychomotor recovery was assessed before colonoscopy and 1 and 2 hours after colonoscopy by using the number connection test and a driving simulator test. Main Outcome Measurements Clinical features, psychomotor recovery, and blood concentration of propofol. Results All patients successfully completed the post-sedation assessments. Although there was a significant difference in results of the number connection test between before colonoscopy and 1 hour after colonoscopy, all number connection test results were within normal limits (<40 seconds). Scores were as follows: mean time (standard deviation) before colonoscopy, 32.2 (2.0) seconds (range 29-36 seconds) versus after colonoscopy, 32.7 (2.0) seconds (range 27-38 seconds); P = .0019. Driving skills had recovered to the baseline levels 1 hour after colonoscopy. Scores were as follows: tracking error (%) before colonoscopy, 45.0 (5.6) versus after colonoscopy, 46.0 (5.5); P = .61; accelerating reaction time in seconds before colonoscopy, 0.65 (0.15) versus after colonoscopy, 0.62 (0.14); P = .40; braking reaction time in seconds before colonoscopy, 0.58 (0.13) versus after colonoscopy, 0.61 (0.13); P = .50. Limitations Small sample size, single-center study. Conclusion Although consistent findings on the number connection test and driving simulation (psychomotor recovery) test are present as early as 1 hour after propofol sedation, a study of additional numbers of patients as well as different patient populations are needed before these results can be universally recommended.</abstract><cop>Maryland heights, MO</cop><pub>Mosby, Inc</pub><pmid>22115604</pmid><doi>10.1016/j.gie.2011.08.020</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Colonoscopy Conscious Sedation Digestive system. Abdomen Endoscopy Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Humans Hypnotics and Sedatives - blood Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Propofol - blood Prospective Studies Psychomotor Performance Recovery of Function |
| title | Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation |
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