Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the s...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2012-02, Vol.131 (2), p.1296-1306
Main Authors: Jacobs, Peter G., Konrad-Martin, Dawn, Mcmillan, Garnett P., McDermott, Daniel, Fausti, Stephen A., Kagen, David, Wan, Eric A.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Audiometry, Evoked Response
Blood Glucose - metabolism
Case-Control Studies
Cochlea - physiology
Diabetes Mellitus, Type 2 - physiopathology
Female
Humans
Hyperglycemia - physiopathology
Male
Middle Aged
Neural Inhibition - physiology
Olivary Nucleus - physiology
Otoacoustic Emissions, Spontaneous - physiology
Physiological Acoustics
Reflex, Acoustic - physiology
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Summary:Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the six subjects were tested twice for a total of 11 trials and three subjects were tested in a control experiment. During the GTT experiment, the subjects' blood glucose was elevated from a euglycemic level below 150mg/dL to a hyperglycemic level above 160mg/dL following the consumption of a bolus of 80g of sugar. A subset of three subjects were tested in a control experiment during which SF OAE and MOC reflex measurements were made while blood sugar levels remained constant within the euglycemic region. Mean SF OAE amplitudes were elevated following glucose consumption. A statistically significant increase in MOC inhibition amplitude was observed during elevated sugar levels for the 11 GTT trials. Maximum inhibition occurred about an hour after glucose consumption when blood glucose levels peaked. Results indicate that acute hyperglycemia influences efferent control of the cochlea in people with type 2 diabetes.
ISSN:0001-4966
1520-8524
DOI:10.1121/1.3676609