Getting back to zero with nucleated red blood cells: following trends is not necessarily a bad thing

Abstract Background The presence of nucleated red blood cells (NRBCs) has been identified as a poor prognostic indicator. We investigated the relationship of NRBC trends in patients with and without trauma. Methods We retrospectively reviewed surgical intensive care unit admissions over 4 years, cat...

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Bibliographic Details
Published in:The American journal of surgery 2012-03, Vol.203 (3), p.343-346
Main Authors: Shah, Rupen, M.D, Reddy, Subhash, M.D, Horst, H. Mathilda, M.D, Stassinopoulos, Jerry, M.D, Jordan, Jack, M.A, Rubinfeld, Ilan, M.D., M.B.A
Format: Article
Language:English
Subjects:
Acids
Acuity predictors
Biological and medical sciences
Biomarkers - blood
Blood tests
Critical Illness - mortality
Cytokines
Disease
Erythroblasts - metabolism
Erythrocyte Count
Erythrocytes
General aspects
Hospital Mortality
Hospitals
Humans
Intensive care
Intensive Care Units - statistics & numerical data
Length of Stay - statistics & numerical data
Markers
Medical sciences
Mortality
Patients
Prognosis
Quality
Retrospective Studies
Surgery
Surgical outcomes
Trauma
Trends
Wounds and Injuries - metabolism
Wounds and Injuries - mortality
Wounds and Injuries - surgery
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Summary:Abstract Background The presence of nucleated red blood cells (NRBCs) has been identified as a poor prognostic indicator. We investigated the relationship of NRBC trends in patients with and without trauma. Methods We retrospectively reviewed surgical intensive care unit admissions over 4 years, categorizing trauma and nontrauma patients and subdividing them into 3 groups: group A, all-zero NRBC; group B, positive NRBC value returning to zero; and group C, positive NRBC value that did not return to zero. We analyzed all groups for outcomes of length of stay and mortality. Results Group A was the largest and had the shortest length of stay and least mortality. Group C had the highest mortality rate. No statistical difference was observed with mortality. Conclusions Any positive NRBC was associated with poor outcome, and increasing NRBC was associated with increasing mortality. Trends in NRBC values showed that returning to zero was protective.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2011.10.002