Angiogenin and Hemoxygenase in Pregnancy: Influence of Hypertension

The pathophysiology of hypertension and preeclampsia involves angiogenesis and endothelial damage/dysfunction, as shown by abnormal growth factors (vascular endothelial growth factor [VEGF], and its receptor sFlt-1) and von Willebrand factor (vWf) in the plasma. Angiogenin and hemoxygenase are abnor...

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Bibliographic Details
Published in:Angiology 2012-04, Vol.63 (3), p.194-198
Main Authors: Karthikeyan, Velore J., Lip, Gregory Y. H., Baghdadi, Sabah, Lane, Deirdre A., Beevers, D. Gareth, Blann, Andrew D.
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Case-Control Studies
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cross-Sectional Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Heme Oxygenase-1 - blood
Humans
Hypertension - blood
Hypertension - enzymology
Medical sciences
Pregnancy
Pregnancy Complications, Cardiovascular - blood
Pregnancy Complications, Cardiovascular - enzymology
Ribonuclease, Pancreatic - blood
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor Receptor-1 - blood
von Willebrand Factor - metabolism
Young Adult
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Summary:The pathophysiology of hypertension and preeclampsia involves angiogenesis and endothelial damage/dysfunction, as shown by abnormal growth factors (vascular endothelial growth factor [VEGF], and its receptor sFlt-1) and von Willebrand factor (vWf) in the plasma. Angiogenin and hemoxygenase are abnormal in hypertension and angiogenesis but data on pregnancy are scant. We hypothesized altered angiogenin and hemoxygenase in 38 hypertensive pregnant women (HTPW) compared to 38 normotensive pregnant women (NTPW) and 50 nonpregnant controls (NonPCs). Plasma markers were measured by enzyme-linked immunosorbent assay (ELISA). Hypertensive pregnant women had lower VEGF than NonPCs (P < .01), vWf was raised in both pregnant groups (P < .01), but sFlt-1 was no different. Both angiogenin and hemoxygenase were lower in NTPW compared to NonPCs (both p .33, P < .05), but in NonPCs this was not significant (r = .13, P = .367). These changes may reflect differences in endothelial cell physiology and pathology in the hypertension in pregnancy.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319711410308