Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease

Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whet...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2012-03, Vol.27 (3), p.1064-1070
Main Authors: CHEN, Szu-Chia, CHANG, Jer-Ming, LIU, Wan-Chun, HUANG, Jiun-Chi, TSAI, Jer-Chia, LIN, Ming-Yen, SU, Ho-Ming, HWANG, Shang-Jyh, CHEN, Hung-Chun
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Echocardiography
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
Incidence
Intensive care medicine
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - mortality
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Prognosis
Renal failure
Risk Assessment
Survival Rate
Taiwan - epidemiology
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Summary:Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whether echocardiographic parameters are independently associated with increased CV events in patients with CKD Stages 3-5. We consecutively enrolled 505 CKD patients from our outpatient department of internal medicine. CV events were defined as CV death, hospitalization for unstable angina, non-fatal myocardial infarction, sustained ventricular arrhythmia, hospitalization for congestive heart failure, transient ischemia attack and stroke. The relative CV events' risk was analyzed by Cox regression methods. In the multivariate analysis, old age, the presence of diabetes, coronary artery disease and atrial fibrillation; decreased serum albumin and hematocrit levels; left atrial diameter (LAD) >4.7 cm [hazard ratio (HR), 2.141; 95% confidence interval (CI), 1.155-3.971, P = 0.016]; increased left ventricular mass index (LVMI) (HR, 1.006; 95% CI, 1.002 to 1.010, P = 0.003) and left ventricular ejection fraction (LVEF) 4.7 cm, increased LVMI and LVEF
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfr407