Loading…
Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease
Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whet...
Saved in:
| Published in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2012-03, Vol.27 (3), p.1064-1070 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243 |
| container_end_page | 1070 |
| container_issue | 3 |
| container_start_page | 1064 |
| container_title | Nephrology, dialysis, transplantation |
| container_volume | 27 |
| creator | CHEN, Szu-Chia CHANG, Jer-Ming LIU, Wan-Chun HUANG, Jiun-Chi TSAI, Jer-Chia LIN, Ming-Yen SU, Ho-Ming HWANG, Shang-Jyh CHEN, Hung-Chun |
| description | Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whether echocardiographic parameters are independently associated with increased CV events in patients with CKD Stages 3-5.
We consecutively enrolled 505 CKD patients from our outpatient department of internal medicine. CV events were defined as CV death, hospitalization for unstable angina, non-fatal myocardial infarction, sustained ventricular arrhythmia, hospitalization for congestive heart failure, transient ischemia attack and stroke. The relative CV events' risk was analyzed by Cox regression methods.
In the multivariate analysis, old age, the presence of diabetes, coronary artery disease and atrial fibrillation; decreased serum albumin and hematocrit levels; left atrial diameter (LAD) >4.7 cm [hazard ratio (HR), 2.141; 95% confidence interval (CI), 1.155-3.971, P = 0.016]; increased left ventricular mass index (LVMI) (HR, 1.006; 95% CI, 1.002 to 1.010, P = 0.003) and left ventricular ejection fraction (LVEF) 4.7 cm, increased LVMI and LVEF |
| doi_str_mv | 10.1093/ndt/gfr407 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_926151461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>926151461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243</originalsourceid><addsrcrecordid>eNpFkMtKw0AUhgdRbK1ufADJRgQhdm7JZJYi9QIFN7oOpzMn7WiaxJlU6Qv43E4v6mYu_N_5D3yEnDN6w6gW48b243nlJVUHZMhkTlMuiuyQDGPIUppRPSAnIbxRSjVX6pgMOCuYKHg2JN8Ts2gNeOvauYdu4UzSgYcl9uhDAh4T11jsMB5NX68TCKE1Dnq0yZfrFzE1HiHE767kE4JZ1eAT_IwDIeaxr3fb93bALHzbxC3vzja4TqwLm_FTclRBHfBsf4_I6_3k5e4xnT4_PN3dTlMjWN6nmgPXiLNKKaW11VhlEgrJuABrmFZSz1Supcw0Y8IUbCaVMlhwgTlDyqUYkatdb-fbjxWGvly6YLCuocF2FUrNc5ZFhSyS1zvS-DYEj1XZebcEvy4ZLTfay6i93GmP8MW-djVbov1Dfz1H4HIPRD9QVx4a48I_l-U0glT8AGpQjrk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>926151461</pqid></control><display><type>article</type><title>Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease</title><source>Oxford Journals Online</source><creator>CHEN, Szu-Chia ; CHANG, Jer-Ming ; LIU, Wan-Chun ; HUANG, Jiun-Chi ; TSAI, Jer-Chia ; LIN, Ming-Yen ; SU, Ho-Ming ; HWANG, Shang-Jyh ; CHEN, Hung-Chun</creator><creatorcontrib>CHEN, Szu-Chia ; CHANG, Jer-Ming ; LIU, Wan-Chun ; HUANG, Jiun-Chi ; TSAI, Jer-Chia ; LIN, Ming-Yen ; SU, Ho-Ming ; HWANG, Shang-Jyh ; CHEN, Hung-Chun</creatorcontrib><description>Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whether echocardiographic parameters are independently associated with increased CV events in patients with CKD Stages 3-5.
We consecutively enrolled 505 CKD patients from our outpatient department of internal medicine. CV events were defined as CV death, hospitalization for unstable angina, non-fatal myocardial infarction, sustained ventricular arrhythmia, hospitalization for congestive heart failure, transient ischemia attack and stroke. The relative CV events' risk was analyzed by Cox regression methods.
In the multivariate analysis, old age, the presence of diabetes, coronary artery disease and atrial fibrillation; decreased serum albumin and hematocrit levels; left atrial diameter (LAD) >4.7 cm [hazard ratio (HR), 2.141; 95% confidence interval (CI), 1.155-3.971, P = 0.016]; increased left ventricular mass index (LVMI) (HR, 1.006; 95% CI, 1.002 to 1.010, P = 0.003) and left ventricular ejection fraction (LVEF) <55% (HR, 2.007; 95% CI, 1.007-3.743, P = 0.028) were independently associated with increased CV events.
Our findings show that LAD >4.7 cm, increased LVMI and LVEF <55% are independently associated with adverse CV outcomes in CKD patients. Screening CKD patients by means of echocardiography may help identify a high-risk group of poor CV prognosis.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr407</identifier><identifier>PMID: 21813825</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Echocardiography ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Humans ; Incidence ; Intensive care medicine ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - mortality ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Prognosis ; Renal failure ; Risk Assessment ; Survival Rate ; Taiwan - epidemiology</subject><ispartof>Nephrology, dialysis, transplantation, 2012-03, Vol.27 (3), p.1064-1070</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243</citedby><cites>FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25601380$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21813825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, Szu-Chia</creatorcontrib><creatorcontrib>CHANG, Jer-Ming</creatorcontrib><creatorcontrib>LIU, Wan-Chun</creatorcontrib><creatorcontrib>HUANG, Jiun-Chi</creatorcontrib><creatorcontrib>TSAI, Jer-Chia</creatorcontrib><creatorcontrib>LIN, Ming-Yen</creatorcontrib><creatorcontrib>SU, Ho-Ming</creatorcontrib><creatorcontrib>HWANG, Shang-Jyh</creatorcontrib><creatorcontrib>CHEN, Hung-Chun</creatorcontrib><title>Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whether echocardiographic parameters are independently associated with increased CV events in patients with CKD Stages 3-5.
We consecutively enrolled 505 CKD patients from our outpatient department of internal medicine. CV events were defined as CV death, hospitalization for unstable angina, non-fatal myocardial infarction, sustained ventricular arrhythmia, hospitalization for congestive heart failure, transient ischemia attack and stroke. The relative CV events' risk was analyzed by Cox regression methods.
In the multivariate analysis, old age, the presence of diabetes, coronary artery disease and atrial fibrillation; decreased serum albumin and hematocrit levels; left atrial diameter (LAD) >4.7 cm [hazard ratio (HR), 2.141; 95% confidence interval (CI), 1.155-3.971, P = 0.016]; increased left ventricular mass index (LVMI) (HR, 1.006; 95% CI, 1.002 to 1.010, P = 0.003) and left ventricular ejection fraction (LVEF) <55% (HR, 2.007; 95% CI, 1.007-3.743, P = 0.028) were independently associated with increased CV events.
Our findings show that LAD >4.7 cm, increased LVMI and LVEF <55% are independently associated with adverse CV outcomes in CKD patients. Screening CKD patients by means of echocardiography may help identify a high-risk group of poor CV prognosis.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Echocardiography</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Prognosis</subject><subject>Renal failure</subject><subject>Risk Assessment</subject><subject>Survival Rate</subject><subject>Taiwan - epidemiology</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpFkMtKw0AUhgdRbK1ufADJRgQhdm7JZJYi9QIFN7oOpzMn7WiaxJlU6Qv43E4v6mYu_N_5D3yEnDN6w6gW48b243nlJVUHZMhkTlMuiuyQDGPIUppRPSAnIbxRSjVX6pgMOCuYKHg2JN8Ts2gNeOvauYdu4UzSgYcl9uhDAh4T11jsMB5NX68TCKE1Dnq0yZfrFzE1HiHE767kE4JZ1eAT_IwDIeaxr3fb93bALHzbxC3vzja4TqwLm_FTclRBHfBsf4_I6_3k5e4xnT4_PN3dTlMjWN6nmgPXiLNKKaW11VhlEgrJuABrmFZSz1Supcw0Y8IUbCaVMlhwgTlDyqUYkatdb-fbjxWGvly6YLCuocF2FUrNc5ZFhSyS1zvS-DYEj1XZebcEvy4ZLTfay6i93GmP8MW-djVbov1Dfz1H4HIPRD9QVx4a48I_l-U0glT8AGpQjrk</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>CHEN, Szu-Chia</creator><creator>CHANG, Jer-Ming</creator><creator>LIU, Wan-Chun</creator><creator>HUANG, Jiun-Chi</creator><creator>TSAI, Jer-Chia</creator><creator>LIN, Ming-Yen</creator><creator>SU, Ho-Ming</creator><creator>HWANG, Shang-Jyh</creator><creator>CHEN, Hung-Chun</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease</title><author>CHEN, Szu-Chia ; CHANG, Jer-Ming ; LIU, Wan-Chun ; HUANG, Jiun-Chi ; TSAI, Jer-Chia ; LIN, Ming-Yen ; SU, Ho-Ming ; HWANG, Shang-Jyh ; CHEN, Hung-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Echocardiography</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Prognosis</topic><topic>Renal failure</topic><topic>Risk Assessment</topic><topic>Survival Rate</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, Szu-Chia</creatorcontrib><creatorcontrib>CHANG, Jer-Ming</creatorcontrib><creatorcontrib>LIU, Wan-Chun</creatorcontrib><creatorcontrib>HUANG, Jiun-Chi</creatorcontrib><creatorcontrib>TSAI, Jer-Chia</creatorcontrib><creatorcontrib>LIN, Ming-Yen</creatorcontrib><creatorcontrib>SU, Ho-Ming</creatorcontrib><creatorcontrib>HWANG, Shang-Jyh</creatorcontrib><creatorcontrib>CHEN, Hung-Chun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, Szu-Chia</au><au>CHANG, Jer-Ming</au><au>LIU, Wan-Chun</au><au>HUANG, Jiun-Chi</au><au>TSAI, Jer-Chia</au><au>LIN, Ming-Yen</au><au>SU, Ho-Ming</au><au>HWANG, Shang-Jyh</au><au>CHEN, Hung-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>27</volume><issue>3</issue><spage>1064</spage><epage>1070</epage><pages>1064-1070</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Patients with chronic kidney disease (CKD) are associated with increased cardiovascular (CV) morbidity and mortality. Echocardiographic measures of heart structure and function have been reported to predict adverse CV outcomes in various pathologic conditions. The aim of this study is to assess whether echocardiographic parameters are independently associated with increased CV events in patients with CKD Stages 3-5.
We consecutively enrolled 505 CKD patients from our outpatient department of internal medicine. CV events were defined as CV death, hospitalization for unstable angina, non-fatal myocardial infarction, sustained ventricular arrhythmia, hospitalization for congestive heart failure, transient ischemia attack and stroke. The relative CV events' risk was analyzed by Cox regression methods.
In the multivariate analysis, old age, the presence of diabetes, coronary artery disease and atrial fibrillation; decreased serum albumin and hematocrit levels; left atrial diameter (LAD) >4.7 cm [hazard ratio (HR), 2.141; 95% confidence interval (CI), 1.155-3.971, P = 0.016]; increased left ventricular mass index (LVMI) (HR, 1.006; 95% CI, 1.002 to 1.010, P = 0.003) and left ventricular ejection fraction (LVEF) <55% (HR, 2.007; 95% CI, 1.007-3.743, P = 0.028) were independently associated with increased CV events.
Our findings show that LAD >4.7 cm, increased LVMI and LVEF <55% are independently associated with adverse CV outcomes in CKD patients. Screening CKD patients by means of echocardiography may help identify a high-risk group of poor CV prognosis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21813825</pmid><doi>10.1093/ndt/gfr407</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 2012-03, Vol.27 (3), p.1064-1070 |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_926151461 |
| source | Oxford Journals Online |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Echocardiography Emergency and intensive care: renal failure. Dialysis management Female Humans Incidence Intensive care medicine Kidney Failure, Chronic - complications Kidney Failure, Chronic - mortality Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Prognosis Renal failure Risk Assessment Survival Rate Taiwan - epidemiology |
| title | Echocardiographic parameters are independently associated with increased cardiovascular events in patients with chronic kidney disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T01%3A54%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Echocardiographic%20parameters%20are%20independently%20associated%20with%20increased%20cardiovascular%20events%20in%20patients%20with%20chronic%20kidney%20disease&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=CHEN,%20Szu-Chia&rft.date=2012-03-01&rft.volume=27&rft.issue=3&rft.spage=1064&rft.epage=1070&rft.pages=1064-1070&rft.issn=0931-0509&rft.eissn=1460-2385&rft.coden=NDTREA&rft_id=info:doi/10.1093/ndt/gfr407&rft_dat=%3Cproquest_cross%3E926151461%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c316t-92a29eebf77799d9ef54a84123adc19749b7694459113c81b477ce823e61e0243%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=926151461&rft_id=info:pmid/21813825&rfr_iscdi=true |