Highly Chemoselective Reduction of Carbonyl Groups in the Presence of Aldehydes

The exquisite ability of diethylaluminum benzenethiolate to efficiently discriminate between aldehydes and other carbonyl functions enables the chemoselective in situ reduction of ketones and methyl esters in the presence of aldehydes. This potent strategy avoids the usual drawbacks of traditional p...

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Bibliographic Details
Published in:Organic letters 2012-03, Vol.14 (5), p.1306-1309
Main Authors: Bastug, Gulluzar, Dierick, Steve, Lebreux, Frédéric, Markó, István E
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Ketones - chemistry
Molecular Structure
Oxidation-Reduction
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Summary:The exquisite ability of diethylaluminum benzenethiolate to efficiently discriminate between aldehydes and other carbonyl functions enables the chemoselective in situ reduction of ketones and methyl esters in the presence of aldehydes. This potent strategy avoids the usual drawbacks of traditional protecting group methodologies and could be extended to various other transformations.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol300188e