Cognitive impairment in antiphospholipid syndrome: evidence from animal models

Although antiphospholipid syndrome (APS) is a multisystem prothrombotic condition, its inflammatory nature has been increasingly recognized in recent years. Stroke and transitory ischemic attacks are the neurological manifestations included in APS criteria, however many other neurological involvemen...

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Bibliographic Details
Published in:Clinical rheumatology 2012-03, Vol.31 (3), p.403-406
Main Authors: Appenzeller, Simone, Lapa, Aline Tamires, Guirau, Caio Rodrigues, de Carvalho, Jozélio Freire, Shoenfeld, Yehuda
Format: Article
Language:English
Subjects:
Animal models
Animals
antiphospholipid antibodies
antiphospholipid syndrome
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - psychology
Cognition Disorders - complications
Cognition Disorders - psychology
Cognitive ability
Disease Models, Animal
Humans
Inflammation
Ischemia
Medicine
Medicine & Public Health
Myelitis
Review Article
Reviews
Rheumatology
Seizures
Stroke
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Summary:Although antiphospholipid syndrome (APS) is a multisystem prothrombotic condition, its inflammatory nature has been increasingly recognized in recent years. Stroke and transitory ischemic attacks are the neurological manifestations included in APS criteria, however many other neurological involvements have been attributed to antiphospholipid antibodies (aPL), such as seizures, transverse myelitis, and cognitive impairment. In this article we will review evidence from animal model that explain the role of aPL in cognition.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-011-1922-z