Cytokine Profiles in Children with Severe Plasmodium falciparum Malaria in an Area of Unstable Malaria Transmission in Central Sudan

Background: Few data exist concerning pathogenesis of severe malaria in areas of unstable malaria transmission. Objectives: The study was conducted in Senga hospital, central Sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in children with severe P...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2011-10, Vol.57 (5), p.392-395
Main Authors: Mirghani, Hiba A., Eltahir, Hatim G., A-Elgadir, Thoraya M., Mirghani, Yousra A., Elbashir, Mustafa I., Adam, Ishag
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
Child
Child, Preschool
General aspects
Human protozoal diseases
Humans
Infant
Infectious diseases
Interferon-gamma - blood
Interleukin-10 - blood
Interleukin-4 - blood
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - immunology
Malaria, Falciparum - transmission
Medical sciences
Parasitic diseases
Plasmodium falciparum
Protozoal diseases
Sudan
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Summary:Background: Few data exist concerning pathogenesis of severe malaria in areas of unstable malaria transmission. Objectives: The study was conducted in Senga hospital, central Sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in children with severe Plasmodium falciparum malaria. Methods: Enzyme-linked immunosorbent assay was used to measure the concentrations of three cytokines, interferon gamma (IFN-γ), interleukin-4 (IL-4) and IL-10, in sera of three groups of children (31 in each arm): those with one or more manifestations of severe malaria, those children with uncomplicated P. falciparum malaria and healthy controls. Results: The levels of both IFN-γ and IL-10 were significantly higher in patients with severe P. falciparum malaria. Medium positive correlations were observed between IFN-γ and IL-10. Conclusion: Thus, the high levels of both IFN-γ and IL-10 indicated their role in the pathogenesis of severe P. falciparum malaria.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmq109