Advances in Proteomics of Mycobacterium leprae

Although Mycobacterium leprae was the first bacterial pathogen identified causing human disease, it remains one of the few that is non‐cultivable. Understanding the biology of M. leprae is one of the primary challenges in current leprosy research. Genomics has been extremely valuable, nonetheless, f...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2012-04, Vol.75 (4), p.369-378
Main Authors: Parkash, O., Singh, B. P.
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - analysis
Bacterial Proteins - immunology
Drugs
genomics
Humans
Leprosy
Leprosy - immunology
Mycobacterium leprae
Mycobacterium leprae - chemistry
Mycobacterium leprae - immunology
Pathogens
Proteome - analysis
Proteome - immunology
proteomics
Proteomics - methods
Vaccines
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Summary:Although Mycobacterium leprae was the first bacterial pathogen identified causing human disease, it remains one of the few that is non‐cultivable. Understanding the biology of M. leprae is one of the primary challenges in current leprosy research. Genomics has been extremely valuable, nonetheless, functional proteins are ultimately responsible for controlling most aspects of cellular functions, which in turn could facilitate parasitizing the host. Furthermore, bacterial proteins provide targets for most of the vaccines and immunodiagnostic tools. Better understanding of the proteomics of M. leprae could also help in developing new drugs against M. leprae. During the past nearly 15 years, there have been several developments towards the identification of M. leprae proteins employing contemporary proteomics tools. In this review, we discuss the knowledge gained on the biology and pathogenesis of M. leprae from current proteomic studies.
ISSN:0300-9475
1365-3083
DOI:10.1111/j.1365-3083.2012.02677.x