The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder

Abstract Background There is evidence that inflammation, oxidative and nitrosative stress (IO&NS) play a role in the pathophysiology of depression. There are also data indicating altered inflammatory gene expression in depressive disorder and that genetic variants of IO&NS genes are associat...

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Bibliographic Details
Published in:Journal of affective disorders 2012-05, Vol.138 (3), p.360-366
Main Authors: Gałecki, Piotr, Gałecka, Elżbieta, Maes, Michael, Chamielec, Marcelina, Orzechowska, Agata, Bobińska, Kinga, Lewiński, Andrzej, Szemraj, Janusz
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antidepressive Agents - therapeutic use
Biological and medical sciences
Blood cells
Cyclooxygenase 2 - genetics
Cyclooxygenase-2
Depression
Depressive Disorder - drug therapy
Depressive Disorder - genetics
Depressive personality disorders
Encoding
Female
Gene Expression
Genes
Group II Phospholipases A2 - genetics
Humans
Inducible nitric oxide synthase
Male
Medical sciences
Middle Aged
Mood disorders
mRNA expression
Myeloperoxidase
Nitric Oxide Synthase Type II - genetics
Pathophysiological aspects
Peroxidase - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Recurrence
RNA, Messenger - biosynthesis
Secretory phospholipase A2
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Summary:Abstract Background There is evidence that inflammation, oxidative and nitrosative stress (IO&NS) play a role in the pathophysiology of depression. There are also data indicating altered inflammatory gene expression in depressive disorder and that genetic variants of IO&NS genes are associated with increased risk of the disease in question. The aim of this study was to explore mRNA expression of four IO&NS genes PTGS2 , MPO , NOS2A , and PLA2G2A coding respectively: cyclooxygenase-2 (COX-2), myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS) and secretory phospholipase A2 type IIA (sPLA2-IIA). Method Expression of the mRNA was determined using quantitative real-time PCR, in peripheral blood cells of patients with recurrent depressive disorder (rDD) and normal controls. Results The mRNA expressions of the genes encoding for COX-2, MPO, iNOS and sPLA2-IIA were significantly increased in the peripheral blood cells of depressed patients versus controls. Limitations Patients were treated with antidepressants. Conclusion Our results indicate and may confirm the role of peripheral IO&NS pathways in the pathophysiology of depression. The results represent a promising way to investigate biological markers of depression.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2012.01.016