Lessons from genome-wide association studies findings in Alzheimer's disease

Alzheimer's disease (AD) is the most common neurodegenerative disorder with a complex genetic background. Recent genome‐wide association studies (GWAS) have placed important new contributors into the genetic framework of early‐ and late‐onset forms of this dementia. Besides confirming the major...

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Bibliographic Details
Published in:Psychogeriatrics 2012-03, Vol.12 (1), p.62-73
Main Authors: MORAES, Clayton F., LINS, Tulio C., CARMARGOS, Einstein F., NAVES, Janeth O. S., PEREIRA, Rinaldo W., NÓBREGA, Otávio T.
Format: Article
Language:English
Subjects:
Age of Onset
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
biomarkers
dementia
Dementia disorders
genetic association
Genetic markers
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Genomes
Genomics
Geriatric psychology
high-throughput screenings
Humans
neurodegeneration
Neurodegenerative diseases
Polymorphism, Single Nucleotide - genetics
Reviews
Risk factors
Single-nucleotide polymorphism
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Summary:Alzheimer's disease (AD) is the most common neurodegenerative disorder with a complex genetic background. Recent genome‐wide association studies (GWAS) have placed important new contributors into the genetic framework of early‐ and late‐onset forms of this dementia. Besides confirming the major role of classic allelic variants (e.g. apolipoprotein E) in the development of AD, GWAS have thus far implicated over 20 single nucleotide polymorphisms in AD. In this review, we summarize the findings of 16 AD‐based GWAS performed to date whose public registries are available at the National Human Genome Research Institute, with an emphasis on understanding whether the polymorphic markers under consideration support functional implications to the pathophysiological role of the major genetic risk factors unraveled by GWAS.
ISSN:1346-3500
1479-8301
DOI:10.1111/j.1479-8301.2011.00378.x