Chronic depressive symptoms and Framingham coronary risk in HIV-infected and HIV-uninfected women

• Published in: AIDS care 2012-03, Vol.24 (3), p.394-403
• Main Authors: Schwartz, Rebecca M., Mansoor, Ather, Wilson, Tracey E., Anastos, Kathryn, Everson-Rose, Susan A., Golub, Elizabeth T., Goparaju, Lakshmi, Hessol, Nancy A., Mack, Wendy J., Lazar, Jason
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - psychology; Comorbidity; Coronary Risk; Depression; Depression - epidemiology; Depression - psychology; Diagnosis; Female; Follow-Up Studies; Framingham; Heart disease; HIV; HIV Infections - epidemiology; HIV Infections - psychology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Mental depression; Mental health; Mood disorders; Mortality; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk; Risk assessment; Risk Factors; Risk reduction; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Women; Women's Health
• ISSN: 0954-0121; 1360-0451
• DOI: 10.1080/09540121.2011.608791

Depression is common in people with cardiovascular diseases (CVD) and those with HIV, and is a risk factor for CVD-related mortality. However, little is known about whether HIV influences the relationship between depression and cardiovascular risk. A total of 526 HIV-infected and 132 uninfected women from the Women's Interagency HIV Study were included in an analysis of women who completed twice-yearly study visits over 9.5 years. CVD risk was calculated at baseline and approximately 9.5 years later using the Framingham Risk Score (FRS). Chronic depressive symptoms were defined as Center for Epidemiologic Studies Depression Scale scores of 16 or greater at ≥75% of study visits. Over the follow-up period, 22.8% of HIV-infected women and 15.9% of HIV-uninfected women had chronic depressive symptoms (p=0.08). Baseline FRS was similar between HIV-infected and uninfected women (M=−5.70±SE=0.30 vs. M=−6.90± SE=0.60, p=0.07) as was follow-up FRS (M=0.82±SE=0.30 vs. M=−0.44± SE=0.73, p=0.11). Among HIV-infected and HIV-uninfected women, together, follow-up FRS was higher among women with chronic depressive symptoms as compared to those without (M=1.3± SE=0.6 vs. M=−0.3± SE=0.40, p